Association between the rate of third generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption based on 143 Chinese tertiary hospitals data in 2014
Association between the rate of third generation cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption based on 143 Chinese tertiary hospitals data in 2014
复制标题
2014年中国143家三级医院数据第三代头孢菌素耐药大肠埃希菌和肺炎克雷伯菌率与抗生素使用量的关系
DOI：
10.1007/s10096-020-03856-1
复制
发表时间：
2020-03-27
影响因子：
4.5
通讯作者：
Xiao, Yonghong
中科院分区：
文献类型：
--
作者：
Yang, Ping;Chen, Yunbo;Xiao, Yonghong
本研究旨在探讨2014年中国143家三级医院第三代头孢菌素（3GC）耐药大肠埃希菌和肺炎克雷伯菌与抗生素使用强度的相关性。采用回顾性研究设计，探讨抗生素使用量与耐3GC大肠埃希菌的相关性。埃希菌和pneumoniae进行。3GC抗性E.大肠埃希菌感染与抗生素使用量呈显著相关（r = 0.252，p < 0.01），β-内酰胺类抗生素（r = 0.313，p < 0.01），β-内酰胺类（不包括与β-内酰胺酶抑制剂的组合）（r = 0.365，p < 0.01），头孢菌素类（r = 0.398，P < 0.01），头孢菌素类不包括与β-内酰胺酶抑制剂的联合用药（r = 0.374，p < 0.01），3GC（r = 0.321，p < 0.01），和3GC排除与β-内酰胺酶抑制剂的组合（r = 0.343，p < 0.01）。3GC抗性K.肺炎与所有抗生素的使用量显著相关（r = 0.200，p < 0.05），β-内酰胺类抗生素（r = 0.232，p < 0.01），头孢菌素类（r = 0.215，p < 0.05），3GC（r = 0.383，p < 0.01），3GC排除与β-内酰胺酶抑制剂的组合（r = 0.245，p < 0.01），和β-内酰胺-β-内酰胺酶抑制剂组合（r = 0.218，p < 0.05）。耐3GC大肠埃希菌的检出率与抗生素使用量有显著相关性。埃希菌和肺炎。临床医师应掌握抗生素的使用适应证，减少耐药菌的产生。
This study sought to discuss the correlation between the third-generation cephalosporins (3GC)-resistant Escherichia coli and Klebsiella pneumoniae and antibiotic consumption intensity from 143 Chinese tertiary hospitals in 2014. With a retrospective design, the correlation between antibiotic consumption and 3GC-resistant E. coli and K. pneumoniae were performed. 3GC-resistant E. coli was significantly correlated with the consumption of all antibiotics (r = 0.252, p < 0.01), β-Lactams antibiotics (r = 0.313, p < 0.01), β-Lactams excluding combinations with β-lactamase inhibitors (r = 0.365, p < 0.01), cephalosporin (r = 0.398, p < 0.01), cephalosporins excluding combinations with β-lactamase inhibitors (r = 0.374, p < 0.01), 3GC (r = 0.321, p < 0.01), and 3GC excluding combinations with β-lactamase inhibitors (r = 0.343, p < 0.01). 3GC-resistant K. pneumoniae was significantly correlated with the consumption of all antibiotics (r = 0.200, p < 0.05), β-Lactams antibiotics (r = 0.232, p < 0.01), cephalosporin (r = 0.215, p < 0.05), 3GC (r = 0.383, p < 0.01), 3GC excluding combinations with β-lactamase inhibitors (r = 0.245, p < 0.01), and β-lactam-β-lactamase inhibitor combinations (r = 0.218, p < 0.05). There was a significant relationship between the antibiotic consumption and the rates of 3GC-resistant E. coli and K. pneumoniae. Clinicians should grasp the indication of antibiotics use to reduce the production of drug-resistant bacteria.