Elemental biological imaging by differential absorption with a laser-produced x-ray source
Elemental biological imaging by differential absorption with a laser-produced x-ray source
复制标题
使用激光产生的 X 射线源通过差分吸收进行元素生物成像
DOI：
10.1364/josab.13.000209
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发表时间：
1996
影响因子：
1.9
通讯作者：
K. Herrlin
中科院分区：
文献类型：
--
作者：
C. Tillman;I. Mercer;S. Svanberg;K. Herrlin
我们展示了新的应用硬x射线发射的激光产生的等离子体差分成像的元素。X射线发射激光产生的等离子体，通过聚焦来自10赫兹太瓦激光器的辐射获得，用于生物成像。X射线源可以被布置为产生具有光子能量的特征X射线发射线，所述光子能量桥接所选原子种类的K吸收边。人们可以通过在数字图像板上记录不同目标材料的透照图像并随后减去或除以图像来获得元素特定的射线照片。利用钽和钆作为太瓦激光器的靶材料和钆作为成像造影剂，成功地进行了体模和实验动物成像。
We demonstrate the novel application of hard x rays emitted by a laser-produced plasma for differential imaging of elements. An x-ray-emitting laser-produced plasma, obtained by the focusing of radiation from a 10-Hz terawatt laser, is used for biological imaging. The x-ray source can be arranged to yield characteristic x-ray emission lines with photon energies that bridge the K absorption edge of a chosen atomic species. One can obtain element-specific radiographs by recording transillumination images for different target materials on digital image plates and by subsequently subtracting or dividing the images. Successful phantom and experimental animal imaging are performed utilizing tantalum and gadolinium as target materials for the terawatt laser and gadolinium as the imaged contrast agent.