Selective opiate modulation of nociceptive processing in the human brain
Selective opiate modulation of nociceptive processing in the human brain
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DOI：
10.1152/jn.2000.84.1.525
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Minoshima, S
中科院分区：
文献类型：
--
作者：
Casey, KL;Svensson, P;Minoshima, S
芬太尼是一种阿片受体激动剂，在保持振动触觉完整的同时产生镇痛作用。我们使用正电子发射断层扫描（PET）研究了在健康的右撇子男性（18-28岁）中介导这种特殊效应的机制。受试者在静脉注射芬太尼（1.5 μ g/kg）或安慰剂（生理盐水）前后分别接受疼痛性冷刺激（n = 11）或无痛性振动刺激（n = 9）。与冷水（29摄氏度）相比，将手浸泡在冰水（1摄氏度）中会感到疼痛，并在对侧第二体感（S2）和岛叶皮层、双侧丘脑和小脑以及小脑皮层内侧的区域脑血流量（rCBF）显著增加。响应值略低于统计阈值(3.5，
Fentanyl, a mu-opioid receptor agonist, produces analgesia while leaving vibrotactile sensation intact. We used positron emission tomography (PET) to study the mechanisms mediating this specific effect in healthy, right-handed human males (ages 18-28 yr). Subjects received either painful cold (n = 11) or painless vibratory (n = 9) stimulation before and after the intravenous injection of fentanyl (1.5 mu g/kg) or placebo (saline). Compared with cool water (29 degrees C), immersion of the hand in ice water (1 degrees C) is painful and produces highly significant increases in regional cerebral blood flow (rCBF) within the contralateral second somatosensory (S2) and insular cortex, bilaterally in the thalamus and cerebellum, and medially in the cerebellar vermis. Responses just below the statistical threshold (3.5,