Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism
Cannabis use and age at onset of psychosis: further evidence of interaction with COMT Val158Met polymorphism
复制标题
DOI：
10.1111/j.1600-0447.2010.01665.x
复制
发表时间：
2011-06-01
影响因子：
6.7
通讯作者：
Fananas, L.
中科院分区：
文献类型：
--
作者：
Estrada, G.;Fatjo-Vilas, M.;Fananas, L.
目的：在一个年轻的精神病患者样本中，（n = 157，平均年龄17.01岁（SD = 3.6））i）首次使用大麻的年龄和出现精神疾病的年龄是否相关，以及ii）这种关系是否受到COMT基因中Val 158 Met多态性的调节。从80名精神分裂症谱系障碍住院患者和77名其他非精神病性障碍住院患者中获得大麻使用概况和COMT Val 158 Met基因型。首先，首次使用大麻的年龄与精神分裂症谱系和其他精神疾病组的发病年龄相关：那些较早开始使用大麻的人在精神疾病发病时的年龄较早。其次，Val 158 Met基因型的分布在诊断组之间或大麻使用者和非使用者之间没有差异。第三，Val 158 Met基因型和大麻的使用之间的相互作用，特别是在出现的精神疾病的年龄，观察到瓦尔/瓦尔基因型载体表现出较早的发病年龄比Met carrier.Conclusion：我们的研究结果表明，暴露于大麻发生的大脑成熟的时间的重要性。COMT Val 158 Met基因型似乎调节大麻与精神病发作年龄之间的关联。这些结果与以前的研究一致。
Objective: To examine, in a sample of young psychiatric patients, (n = 157, mean age 17.01 years (SD = 3.6)) whether i) age at first cannabis use and age at emergence of psychiatric disorders are related and ii) such a relationship is modulated by the Val158Met polymorphism in the COMT gene.Method: Cannabis use profiles and COMT Val158Met genotypes were obtained from 80 inpatients with schizophrenia-spectrum disorders and 77 inpatients with other non-psychotic disorders.Results: First, age at first cannabis use correlates with age at onset in both schizophrenia-spectrum and other psychiatric disorder groups: those who started using cannabis earlier had an earlier age at onset of psychiatric disorders. Second, the distribution of the Val158Met genotypes was not different either between diagnosis groups or between cannabis users and non-users. Third, an interaction between Val158Met genotypes and cannabis use was observed specifically on age at emergence of psychotic disorders, with Val/Val genotype carriers showing an earlier age at onset than Met carriers.Conclusion: Our results suggest the importance of brain maturation timing in which exposure to cannabis occurs. The COMT Val158Met genotype seems to modulate the association between cannabis and age at onset of psychotic disorders. These results are consistent with previous studies.