Somatic transposition in the brain has the potential to influence the biosynthesis of metabolites involved in Parkinson's disease and schizophrenia
Somatic transposition in the brain has the potential to influence the biosynthesis of metabolites involved in Parkinson's disease and schizophrenia
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DOI：
10.1186/1745-6150-7-41
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发表时间：
2012-11-23
期刊：
影响因子：
5.5
通讯作者：
Abrusan, Gyorgy
中科院分区：
文献类型：
--
作者：
Abrusan, Gyorgy
最近发现转座元件在哺乳动物的大脑中表现出很高的活性，然而，到目前为止，它们对其功能的影响程度还不清楚。在本文中，我使用流量平衡分析来检测体细胞逆转位对脑代谢的影响，以及包括神经递质在内的关键代谢物的生物合成。分析表明，人脑中的体细胞移位可以影响包括多巴胺、5-羟色胺和谷氨酸在内的250多种代谢物的生物合成，代谢效应在个体之间表现出很大的差异性，可能有助于帕金森氏症和精神分裂症的发展。
It has been recently discovered that transposable elements show high activity in the brain of mammals, however, the magnitude of their influence on its functioning is unclear so far. In this paper, I use flux balance analysis to examine the influence of somatic retrotransposition on brain metabolism, and the biosynthesis of its key metabolites, including neurotransmitters. The analysis shows that somatic transposition in the human brain can influence the biosynthesis of more than 250 metabolites, including dopamine, serotonin and glutamate, shows large inter-individual variability in metabolic effects, and may contribute to the development of Parkinson's disease and schizophrenia.