Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions
Efficient enantioselective additions of terminal alkynes and aldehydes under operationally convenient conditions
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DOI：
10.1021/ol026282k
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发表时间：
2002-07-25
期刊：
影响因子：
5.2
通讯作者：
Carreira, EM
中科院分区：
文献类型：
--
作者：
Boyall, D;Frantz, DE;Carreira, EM
[图解]在含84-1000ppmH2O的试剂级溶剂中，锌(OTf)(2)和N-甲基麻黄碱催化的末端乙炔和醛的不对称加成反应可以进行。产物的分离产率高，对映体选择性高(最高可达99%ee)。
[GRAPHICS]The enantioselective addition reaction of terminal acetylenes and aldehydes mediated by Zn(OTf)(2) and N-methyl ephedrine can be conducted with reagent grade solvent containing 84-1000 ppm H2O. The products can be isolated in high yield and useful enantioselectivities (up to 99% ee).