Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis.
Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis.
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DOI：
10.5009/gnl17569
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发表时间：
2019-01-15
期刊：
影响因子：
3.4
通讯作者：
Park YN
中科院分区：
文献类型：
--
作者：
Choi J;Chung T;Rhee H;Kim YJ;Jeon Y;Yoo JE;Noh S;Han DH;Park YN
赖氨酸氧化酶样2 （LOXL2）是一种胶原修饰酶，与癌症的侵袭和转移有关。我们通过免疫组织化学方法评估了105例切除的肝细胞癌（hcc）中LOXL2蛋白、碳酸酐酶IX （CAIX）、角蛋白19、上皮细胞粘附分子和白细胞介素6的表达。14.3%（15/105）的hcc中LOXL2阳性，与血清α-胎蛋白水平高、分化差、纤维间质、门静脉侵犯、TNM分期晚期相关（p均<0.05）。此外，LOXL2阳性与CAIX （p=0.005）和间质白细胞介素6表达（p=0.001）显著相关。99例HCC患者的生存分析显示LOXL2阳性是一个不良预后因素；其预后影响出现在进展期hcc中。此外，LOXL2阳性被证明是总生存和疾病特异性生存的独立预测因子（均p<0.05）。有趣的是，LOXL2和CAIX的共表达也是总生存率、疾病特异性生存率、无病生存率和肝外无复发生存率的独立预测因子（均p<0.05）。LOXL2表达代表HCC的一个亚组，具有更强的侵袭性行为，被认为是HCC患者预后不良的标志。
Lysyl oxidase-like 2 (LOXL2), a collagen-modifying enzyme, has been implicated in cancer invasiveness and metastasis. We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. LOXL2 positivity was found in 14.3% (15/105) of HCCs, and it was significantly associated with high serum α-fetoprotein levels, poor differentiation, fibrous stroma, portal vein invasion, and advanced TNM stage (p<0.05 for all). Additionally, LOXL2 positivity was significantly associated with CAIX (p=0.005) and stromal interleukin 6 expression (p=0.001). Survival analysis of 99 HCC patients revealed LOXL2 positivity to be a poor prognostic factor; its prognostic impact appeared in progressed HCCs. Furthermore, LOXL2 positivity was shown to be an independent predictor of overall survival and disease-specific survival (p<0.05 for all). Interestingly, co-expression of LOXL2 and CAIX was also an independent predictor for overall survival, disease-specific survival, disease-free survival, and extrahepatic recurrence-free survival (p<0.05 for all). LOXL2 expression represents a subgroup of HCCs with more aggressive behavior and is suggested to be a poor prognostic marker in HCC patients.
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影响因子：
4.3
作者：
Cox TR;Erler JT
通讯作者：
Erler JT
影响因子：
2.8
作者：
Kockar, Feray;Yildrim, Hatice;Said, Harun M.
通讯作者：
Said, Harun M.
DOI：
10.1083/jcb.201102147
发表时间：
2012-02-20
期刊：
The Journal of cell biology
影响因子：
--
作者：
Lu P;Weaver VM;Werb Z
通讯作者：
Werb Z
影响因子：
168.9
作者：
Bruix, Jordi;Qin, Shukui;Han, Guohong
通讯作者：
Han, Guohong
影响因子：
11.4
作者：
Peinado, H;Iglesias-de la Cruz, MD;Portillo, F
通讯作者：
Portillo, F