Association of the PIG3 promoter polymorphism with invasive bladder cancer in a Japanese population
Association of the PIG3 promoter polymorphism with invasive bladder cancer in a Japanese population
复制标题
DOI：
10.1093/jjco/hyi225
复制
发表时间：
2006-02-01
影响因子：
2.4
通讯作者：
Ogawa, O
中科院分区：
文献类型：
--
作者：
Ito, M;Nishiyama, H;Ogawa, O
PIG3(P53诱导基因3)是TP53的靶点之一，参与细胞凋亡。PIG3的启动子含有可变数量的五核苷酸串联重复序列(VNTRs)n(Y=C或T)，并且VNTRs的数量被报道与TP53的激活有关。本研究利用338例正常对照和273例膀胱癌患者的基因组DNA，分析了PIG3基因启动子VNTRs在膀胱癌中的临床意义。PIG3启动子VNTRs的等位基因频率在两组间差异无统计学意义。然而，等位基因重复数不超过14个与较高的肿瘤级别(P=0.038)和较高的相对危险度(调整后的优势比=2.31，95%可信区间=1.0 5~5.90)相关。提示PIG3启动子VNTRs与浸润性膀胱癌的发生有关。
PIG3 (p53-induced gene 3) is one of the targets of TP53 and is involved in apoptosis. The promoter of PIG3 contains a variable number of tandem repeats (VNTRs) of pentanucleotides (TGYCC)n (Y = C or T) and the number of VNTRs was reported to be correlated with the activation by TP53. In this study, the clinical significance of the PIG3 promoter VNTRs was analyzed in the bladder cancer patients using the genome DNAs from 338 controls and 273 bladder cancer patients. There was no significant difference in the allele frequency of the PIG3 promoter VNTRs between them. However, the presence of 14 or less repeats allele was associated with higher cancer grade (P = 0.038) and higher stage in relative risk (adjusted odds ratio = 2.31, 95% confidence interval = 1.05-5.90). These data suggested that the PIG3 promoter VNTRs was associated with generation of invasive bladder cancer.