Physical activity and 10-year mortality from cardiovascular diseases and all causes - The Zutphen Elderly Study
Physical activity and 10-year mortality from cardiovascular diseases and all causes - The Zutphen Elderly Study
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DOI：
10.1001/archinte.158.14.1499
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发表时间：
1998-07-27
影响因子：
--
通讯作者：
Kromhout, D
中科院分区：
文献类型：
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作者：
Bijnen, FCH;Caspersen, CJ;Kromhout, D
背景：人们对老年人的体力活动和死亡风险知之甚少。因此，我们描述了老年男性的体力活动模式与心血管疾病 (CVD)、特别是冠心病 (CHD) 和中风以及所有原因导致的死亡率之间的关联。方法：通过针对退休男性的经过验证的问卷调查，对 802 名基线年龄为 64 至 84 岁的荷兰男性样本进行了自我报告的体力活动评估。根据身体活动时间的三分位数（参考，最低三分位数）估算了 CVD（199 例死亡）、CHD（90 例）、中风（47 例）和所有原因（373 例）导致的 10 年死亡率的相对风险。对基线年龄、相关主要慢性疾病、吸烟和饮酒进行了调整。结果：CVD 和所有原因导致的死亡风险随着体力活动的增加而降低（趋势 P =.04），总体力活动最高三分位数的调整后相对风险分别为 0.70（95% 置信区间，0.48-1.01）和 0.77（95% 置信区间，0.59-1.00）。除冠心病外，进行强度较大的活动（每小时大于或等于 4 kcal/kg）的时间与所有死亡率结果的相关性均高于强度较低的活动，但没有任何一种活动具有特别的保护作用。每周步行或骑自行车至少 3 次，每次 20 分钟（根据一般健康建议对活动的定义）可降低 CVD 死亡率（调整后相对风险，0.69；95% 置信区间，0.50-0.88）和所有原因死亡率（相对风险，0.71；95% 置信区间，0.58-0.88）。对生物心血管危险因素的额外调整不会影响任何关联的强度。结论：在一般老年男性群体中，体力活动可以预防心血管疾病和所有原因造成的死亡。
Background: Little is known about physical activity and mortality risk in the elderly. Therefore, we describe the associations between the physical activity pattern of elderly men and the mortality from cardiovascular diseases (CVDs), particularly coronary heart disease (CHD) and stroke, and all causes.Methods: Self-reported physical activity was assessed with a validated questionnaire for retired men in a population-based sample of 802 Dutch men, aged 64 to 84 years at baseline. Relative risks were estimated for 10-year mortality from CVD (199 deaths), CHD (90), stroke (47), and all causes (373) for tertiles of time spent on physical activity (reference, lowest tertile). Adjustments were made for baseline age, relevant major chronic diseases, cigarette smoking, and alcohol consumption.Results: Mortality risks from CVD and all causes decreased with increasing physical activity (P for trend =.04) with adjusted relative risks of 0.70 (95% confidence interval, 0.48-1.01) and 0.77 (95% confidence interval, 0.59-1.00) in the highest tertile of total physical activity, respectively. Except for CHD, time spent in more intense activities (greater than or equal to 4 kcal/kg per hour) was more strongly associated with all mortality outcomes than less intense activities, but no single type of activity was particularly protective. Walking or cycling at least 3 times per week for 20 minutes tour definition of activity based on general health recommendations) was associated with reduced mortality from CVD (adjusted relative risk, 0.69; 95% confidence interval, 0.50-0.88) and all causes (relative risk, 0.71; 95% confidence interval, 0.58-0.88). Additional adjustment for biological cardiovascular risk factors did not affect the strength of any association.Conclusion: In a general population of elderly men, physical activity may protect against mortality from CVDs and all causes.