Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
Indispensable role of factor for adipocyte differentiation 104 (fad104) in lung maturation
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DOI：
10.1016/j.yexcr.2011.06.003
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发表时间：
2011-09-10
影响因子：
3.7
通讯作者：
Imagawa, Masayoshi
中科院分区：
文献类型：
--
作者：
Kishimoto, Keishi;Nishizuka, Makoto;Imagawa, Masayoshi
脂肪细胞分化因子104（fad104）是脂肪生成和骨生成的调节因子。我们先前的研究表明，fad104缺陷小鼠出生后立即死亡，这表明fad104对新生儿的存活至关重要。然而，这种快速死亡的原因尚不清楚。在这里，我们展示了fad104在新生儿存活中的作用。表型和形态学分析表明，fad104缺陷小鼠死于与发绀相关的肺发育不良，包括肺不张。此外，免疫组织化学显示，FAD 104在发育中的肺中的ATII细胞中强烈表达。最重要的是，肺中的ATII细胞是不成熟的，并且损害了表面活性剂相关蛋白的表达。总的来说，这些结果表明，fad104在肺成熟，特别是ATII细胞的成熟和分化中具有不可或缺的作用。(C)2011 Elsevier Inc. All rights reserved.
Factor for adipocyte differentiation 104 (fad104) is a regulator of adipogenesis and osteogenesis. Our previous study showed that fad104-deficient mice died immediately after birth, suggesting fad 104 to be essential for neonatal survival. However, the cause of this rapid death is unclear. Here, we demonstrate the role of fad104 in neonatal survival. Phenotypic and morphological analyses showed that fad104-deficient mice died due to cyanosis-associated lung dysplasia including atelectasis. Furthermore, immunohistochemistry revealed that FAD104 was strongly expressed in ATII cells in the developing lung. Most importantly, the ATII cells in lungs were immature, and impaired the expression of surfactant-associated proteins. Collectively, these results indicate that fad104 has an indispensable role in lung maturation, especially the maturation and differentiation of ATII cells. (C) 2011 Elsevier Inc. All rights reserved.