Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children
Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in children
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DOI：
10.1038/s41405-019-0026-8
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发表时间：
2019-12-09
期刊：
影响因子：
3
通讯作者：
Evans, Veronica
中科院分区：
文献类型：
--
作者：
Amaechi, Bennett T.;AbdulAzees, Parveez Ahamed;Evans, Veronica
目的比较含羟基磷灰石和500ppm氟化物的两种牙膏促进再矿化和抑制龋病发生的效果。材料与方法30名成人进行双臂随机双盲交叉试验，每臂14天，将含10%羟基磷灰石和500ppmF-(氟化胺)的牙膏分别涂在含10%羟基磷灰石和500ppmF-(氟化胺)牙膏中。用显微放射照相法测定试验前和试验后的矿物质丢失和病变深度(LD)。两组间比较(基线与后测)采用单侧t检验，两组间比较采用两个独立均值的双侧t检验。
ObjectiveThis in situ study compared the effectiveness of two toothpastes containing hydroxyapatite or 500ppm fluoride in promoting remineralization and inhibiting caries development.Materials and methodsTwo enamel blocks (human primary teeth), one sound and one with artificially-produced caries lesion, were exposed to toothpaste containing either 10% hydroxyapatite or 500ppm F- (amine fluoride) via intra-oral appliance worn by 30 adults in two-arm double blind randomized crossover study lasting 14 days per arm (ClinicalTrials.gov: NCT03681340). Baseline and post-test mineral loss and lesion depth (LD) were quantified using microradiography. One-sided t-test of one group mean was used for intragroup comparison (baseline vs. post-test), while two-sided t-test of two independent means was used to compare the two toothpaste groups.ResultsPairwise comparison (baseline vs. test) indicated significant (p