Role of Slit/Robo Signaling pathway in Bone Metabolism.
Role of Slit/Robo Signaling pathway in Bone Metabolism.
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DOI：
10.7150/ijbs.66931
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发表时间：
2022
影响因子：
9.2
通讯作者：
Huang D
中科院分区：
文献类型：
--
作者：
Jiang L;Sun J;Huang D
Slit/Robo 信号最初被发现作为轴突引导分子在神经发育中发挥重要作用。近年来，随着研究的深入，Slit/Robo在肿瘤发生、血管生成、细胞迁移、骨稳态等其他生命活动中的作用逐渐被揭示。骨骼是新陈代谢活跃的器官。骨吸收和骨形成通过精确的时空协调密切相关。大量证据表明slit作为一种新的骨耦合因子可以调节骨形成和骨吸收。例如，Slit3可以通过Robo受体促进骨形成并抑制骨吸收，在代谢性骨疾病中具有优异的治疗潜力。尽管一些研究的结论相互矛盾，但都肯定了Slit/Robo信号在调节骨代谢中的重要作用。本文综述了Slit/Robo信号在骨代谢领域的研究进展，简要讨论了现有研究中存在的矛盾，并提出了未来Slit/Robo在骨代谢领域的研究方向。
Slit/Robo signals were initially found to play an essential role in nerve development as axonal guidance molecules. In recent years, with in-depth study, the role of Slit/Robo in other life activities, such as tumor development, angiogenesis, cell migration, and bone homeostasis, has gradually been revealed. Bone is an organ with an active metabolism. Bone resorption and bone formation are closely related through precise spatiotemporal coordination. There is much evidence that slit, as a new bone coupling factor, can regulate bone formation and resorption. For example, Slit3 can promote bone formation and inhibit bone resorption through Robo receptors, which has excellent therapeutic potential in metabolic bone diseases. Although the conclusions of some studies are contradictory, they all affirm the vital role of Slit/Robo signaling in regulating bone metabolism. This paper reviews the research progress of Slit/Robo signaling in bone metabolism, briefly discusses the contradictions in the existing research, and puts forward the research direction of Slit/Robo in the field of bone metabolism in the future.
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DOI：
10.1074/jbc.m800688200
发表时间：
2008-06-06
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Fukuhara N;Howitt JA;Hussain SA;Hohenester E
通讯作者：
Hohenester E
影响因子：
64.5
作者：
Brose, K;Bland, KS;Kidd, T
通讯作者：
Kidd, T
影响因子：
64.5
作者：
Barak, Reut;Yom-Tov, Galit;Opatowsky, Yarden
通讯作者：
Opatowsky, Yarden
影响因子：
4.6
作者：
Croteau, L. -P.;Kao, T. -J.;Kania, A.
通讯作者：
Kania, A.
影响因子：
4
作者：
Croke, Monica;Ross, F. Patrick;Teitelbaum, Steven L.
通讯作者：
Teitelbaum, Steven L.