Recent Progress in Jellyfish Toxin Study
Recent Progress in Jellyfish Toxin Study
复制标题
DOI：
10.1248/jhs.49.337
复制
发表时间：
2003-10
影响因子：
--
通讯作者：
H. Nagai
中科院分区：
文献类型：
--
作者：
H. Nagai
最近，我们报道了一些水母蛋白类毒素的化学性质。这是首次报道的水母蛋白毒素的化学特征。蛋白质类毒素活性成分的分离是研究的关键。我们从三种箱形水母(Cubozoa)中分离出毒素[Carbdea rastoni(C.rastoni)，Carabdea alata(C.alata)和Chiropsalmus ourrigatus(C.square rigatus)]。这些毒素对甲壳类动物具有致死毒性和溶血活性。此外，还对毒素的全长cDNA和推导的氨基酸序列进行了分析。所有这些毒素的相对分子质量都在45 kDa左右，它们的氨基酸序列具有同源性。盒状水母毒素代表了一个新的生物活性蛋白家族。
Recently, we have reported the chemical properties of some jellyfish proteinaceous toxins. These were the first chemical characterizations of jellyfish protein toxins to be reported. The isolation of the proteinaceous toxins in their active forms was the key step in the studies. We isolated the toxins from three box jellyfish (Cubozoa) species [Carybdea rastoni (C. rastoni), Carybdea alata (C. alata), and Chiropsalmus quadrigatus (C. quadrigatus)]. These toxins showed lethal toxicity to crustaceans and hemolytic activity. Furthermore, the full-length cDNAs and the deduced amino acid sequences of the toxins were clarified. All of these toxins have a molecular weight of around 45 kDa and their amino acid sequences showed homology with each other. The box jellyfish toxins represent a novel bioactive protein family.