Pulmonary tuberculoma evaluated by means of FDG PET: Findings in 10 cases
Pulmonary tuberculoma evaluated by means of FDG PET: Findings in 10 cases
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DOI：
10.1148/radiology.216.1.r00jl19117
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发表时间：
2000-07-01
期刊：
影响因子：
19.7
通讯作者：
Chung, JK
中科院分区：
文献类型：
--
作者：
Goo, JM;Im, JG;Chung, JK
目的：描述 2-[氟 18]氟-2-脱氧-D-葡萄糖 (FDG) 正电子发射断层扫描 (PET) 中肺结核的发现。 材料和方法：对 10 名连续接受 PET 并随后被证明患有肺结核的患者进行了分析。 8 例通过楔形切除或肺叶切除术 (n = 7) 或针吸活检 (n = 1) 得到组织病理学证实，2 例通过 2 年以上的临床随访证实患有结核病。 PET 扫描通过使用峰值标准化摄取值进行评估。还回顾了计算机断层扫描 (CT) 和组织病理学结果。 结果：10 个结核瘤中有 9 个在 PET 中显示 FDC 摄取，平均峰值标准化摄取值为 4.2 +/- 2.2 (SD)。 4 名患者证实了与主要异常部位相邻的病灶中 FDC 的摄取（范围为 1.9-3.7）。 CT 扫描显示，7 名患者的最长结节直径平均值为 21 mm +/- 8，并且存在一些分支线状混浊或卫星结节区域，提示肺结核。组织病理学结果为慢性肉芽肿性炎症伴干酪样坏死 (n = 7) 和愈合后的结核伴曲霉菌瘤 (n = 1)。结论：肺结核瘤通常会导致 FDC 摄取增加。这些结果表明，在肉芽肿性病变高发的地理区域，在区分良性和恶性肺部异常时应谨慎解释 FDC PET 结果阳性。
PURPOSE: To describe findings of pulmonary tuberculoma at 2-[fluorine 18]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET).MATERIALS AND METHODS: Ten consecutive patients who underwent PET and subsequently were proved to have pulmonary tuberculoma were analyzed. Tuberculosis was proved histopathologically in eight by means of wedge resection or lobectomy (n = 7) or needle biopsy (n = 1) and in two by means of clinical follow-up for more than 2 years. PET scans were evaluated by using peak standardized uptake values. Computed tomographic (CT) and histopathologic findings also were reviewed.RESULTS: Nine of 10 tuberculomas showed FDC uptake at PET, and the mean peak standardized uptake value was 4.2 +/- 2.2 (SD). FDC uptake (range, 1.9-3.7) in lesions adjacent to main abnormalities was demonstrated in four patients. On CT scans, the mean of the longest nodule diameters was 21 mm +/- 8, and there were some areas of branching linear opacities or satellite nodules that suggested pulmonary tuberculosis in seven patients. Histopathologic findings were chronic granulomatous inflammation with caseation necrosis (n = 7) and healed tuberculosis with aspergilloma (n = 1).CONCLUSION: Pulmonary tuberculoma commonly causes an increase in FDC uptake. These results suggest that in geographic regions with a high prevalence of granulomatous lesions, positive FDC PET results should be interpreted with caution in differentiating benign from malignant pulmonary abnormalities.