A coronary active perfusion system for off-pump coronary artery bypass grafting in an experimental porcine model: the relationship between flow rate and myocardial function.
A coronary active perfusion system for off-pump coronary artery bypass grafting in an experimental porcine model: the relationship between flow rate and myocardial function.
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实验猪模型中用于非体外循环冠状动脉旁路移植的冠状动脉主动灌注系统：流速与心肌功能之间的关系。
DOI：
10.1111/j.1525-1594.2008.00579.x
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发表时间：
2008
影响因子：
2.4
通讯作者：
T. Misaki
中科院分区：
文献类型：
--
作者：
Toshio Doi;H. Kamiya;G. Watanabe;T. Misaki
我们开发了一种冠状动脉主动灌注系统（同步动脉血流保证系统[SAFE-System]）来防止非体外循环冠状动脉搭桥术（CABG）远端吻合期间心肌缺血。本研究的目的是确定安全系统的流量和心肌功能之间的关系。实验猪分为5组：体外分流灌注组（A组，n = 6）；SAFE-System组（B组，n = 6）流速为0.1 mL/拍；0.2 mL/拍流速组（C组，n = 6）；0.3 mL/拍流速组（D组，n = 6）；0.4 mL/拍流速组（E组，n = 6）。局部心肌血流量和左心室功能监测30min。A组心肌局部血流量严重减少（P < 0.001），显著低于其他各组（P < 0.001）。A、D、E组收缩期末期压力-容积关系斜率和负荷前可恢复卒中功关系斜率均低于B、c组。与使用被动外分流器相比，冠状动脉主动灌注系统可提供充足的心肌血流量和血流动力学。当使用0.1或0.2 mL/拍流速时，可以维持左心室功能。冠状动脉主动灌注系统的使用似乎使非体外循环冠状动脉搭桥手术更安全，并可能增加非体外循环旁路移植术的应用。
We developed a coronary active perfusion system (synchronized arterial flow ensuring system [SAFE-System]) to prevent myocardial ischemia during distal anastomosis in off-pump coronary artery bypass grafting (CABG). The purpose of this study was to identify the relationship between the flow rate of the SAFE-System and myocardial function. Studies were performed on pigs, which were divided into five groups: external shunt perfusion group (group A, n = 6); 0.1 mL/beat flow rate for the SAFE-System group (group B, n = 6); 0.2 mL/beat flow rate group (group C, n = 6); 0.3 mL/beat flow rate group (group D, n = 6); and 0.4 mL/beat flow rate group (group E, n = 6). Regional myocardial blood flow and left ventricular function were monitored for 30 min. The regional myocardial blood flow in group A was severely decreased (P < 0.001), and was significantly lower than in the other groups (P < 0.001). The slope of the end-systolic pressure-volume relationship, and the slope of the preload recruitable stroke work relationship in groups A, D, and E were lower than in groups B and C. As compared with the use of a passive external shunt, a coronary active perfusion system provides adequate myocardial blood flow and hemodynamics. It was possible to maintain left ventricular function when using 0.1 or 0.2 mL/beat flow rate. The use of a coronary active perfusion system appears to make the off-pump CABG procedure safer and may increase the application of off-pump bypass grafting.
影响因子：
37.8
作者：
GLOWER, DD;SPRATT, JA;RANKIN, JS
通讯作者：
RANKIN, JS
影响因子：
20.1
作者：
LAINE, GA;ALLEN, SJ
通讯作者：
ALLEN, SJ