Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity.
Mesenchymal Stem Cell: A Friend or Foe in Anti-Tumor Immunity.
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DOI：
10.3390/ijms222212429
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发表时间：
2021-11-18
影响因子：
5.6
通讯作者：
Volarevic V
中科院分区：
文献类型：
--
作者：
Harrell CR;Volarevic A;Djonov VG;Jovicic N;Volarevic V
间充质干细胞（Mesenchymal stem cells, MSCs）是一种自我再生的多能干细胞，能够调节所有参与抗肿瘤免疫的免疫细胞的表型和功能。MSCs调节树突状细胞的抗原呈递特性，影响巨噬细胞和CD4+ T辅助细胞的趋化因子和细胞因子的产生，改变CD8+ T淋巴细胞和自然杀伤细胞的细胞毒性，调节髓源性抑制细胞和T调节细胞的产生和扩增。作为可塑性细胞，MSCs的表型和功能取决于邻近肿瘤浸润免疫细胞的细胞因子谱。根据它们所暴露的肿瘤微环境，MSCs可能获得促和抗致瘤表型，并可能增强或抑制肿瘤生长。由于它们的肿瘤归巢特性，间充质干细胞及其外泌体可能被用作在肿瘤细胞中递送抗肿瘤药物的载体，从而降低肿瘤细胞的活力和侵袭性。由于许多因素影响MSCs在肿瘤微环境中的表型和功能，因此更好地了解调节MSCs、免疫细胞和肿瘤细胞之间串扰的信号通路将为MSCs在癌症免疫治疗中的临床应用铺平道路。在这篇综述文章中，我们总结了目前关于MSCs依赖的抗肿瘤免疫反应调节的分子和细胞机制的知识，并讨论了MSCs治疗恶性疾病的不同见解。
Mesenchymal stem cells (MSCs) are self-renewable, multipotent stem cells that regulate the phenotype and function of all immune cells that participate in anti-tumor immunity. MSCs modulate the antigen-presenting properties of dendritic cells, affect chemokine and cytokine production in macrophages and CD4+ T helper cells, alter the cytotoxicity of CD8+ T lymphocytes and natural killer cells and regulate the generation and expansion of myeloid-derived suppressor cells and T regulatory cells. As plastic cells, MSCs adopt their phenotype and function according to the cytokine profile of neighboring tumor-infiltrated immune cells. Depending on the tumor microenvironment to which they are exposed, MSCs may obtain pro- and anti-tumorigenic phenotypes and may enhance or suppress tumor growth. Due to their tumor-homing properties, MSCs and their exosomes may be used as vehicles for delivering anti-tumorigenic agents in tumor cells, attenuating their viability and invasive characteristics. Since many factors affect the phenotype and function of MSCs in the tumor microenvironment, a better understanding of signaling pathways that regulate the cross-talk between MSCs, immune cells and tumor cells will pave the way for the clinical use of MSCs in cancer immunotherapy. In this review article, we summarize current knowledge on the molecular and cellular mechanisms that are responsible for the MSC-dependent modulation of the anti-tumor immune response and we discuss different insights regarding therapeutic potential of MSCs in the therapy of malignant diseases.
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影响因子：
5.5
作者：
Hassanzadeh A;Altajer AH;Rahman HS;Saleh MM;Bokov DO;Abdelbasset WK;Marofi F;Zamani M;Yaghoubi Y;Yazdanifar M;Pathak Y;Chartrand MS;Jarahian M
通讯作者：
Jarahian M
间充质干细胞通过下调全身性抗肿瘤免疫反应来促进肺癌细胞的转移。
影响因子：
4.3
作者：
Gazdic M;Simovic Markovic B;Jovicic N;Misirkic-Marjanovic M;Djonov V;Jakovljevic V;Arsenijevic N;Lukic ML;Volarevic V
通讯作者：
Volarevic V
影响因子：
5.5
作者：
Liu L;Yu T;Jin Y;Mai W;Zhou J;Zhao C
通讯作者：
Zhao C
影响因子：
3.9
作者：
Heidari, Fahimeh;Razmkhah, Mahboobeh;Erfani, Nasrollah
通讯作者：
Erfani, Nasrollah
影响因子：
2.2
作者：
Magistri, Paolo;Leonard, Stephanie Y.;Sicklick, Jason K.
通讯作者：
Sicklick, Jason K.