Comparison of the migration behavior of nanoparticles based on polyethylene glycol and silica using micellar electrokinetic chromatography
Comparison of the migration behavior of nanoparticles based on polyethylene glycol and silica using micellar electrokinetic chromatography
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使用胶束电动色谱法比较基于聚乙二醇和二氧化硅的纳米颗粒的迁移行为
DOI：
10.1002/jssc.201401086
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
T. Sanata
中科院分区：
文献类型：
--
作者：
M. Kato;M. Sasaki;Y. Ueyama;A. Koga;A. Sano;T. Higashi;T. Sanata
纳米粒子是一种直径小于100 nm的球形粒子，是一种很有前途的无创诊断和治疗的治疗诊断装置。在这项研究中，由聚乙二醇和二氧化硅组成的纳米粒子的制备，并使用毛细管电泳检测其迁移行为。考察了电解质中十二烷基硫酸钠浓度、纳米颗粒尺寸和包裹分子对迁移的影响。电解液中添加十二烷基硫酸钠对聚乙二醇纳米粒子的电泳迁移率有显著影响，而对二氧化硅纳米粒子的影响较小。至于尺寸效应，对于聚乙二醇和二氧化硅纳米颗粒两者，对于较小的纳米颗粒尺寸，流动性变得稍快。包裹的分子通过与十二烷基硫酸钠之间的相互作用影响纳米颗粒的流动性。我们提出十二烷基硫酸钠对聚乙二醇纳米颗粒迁移的巨大影响是由于纳米颗粒内的大空间。这些结果表明，纳米颗粒迁移主要由纳米颗粒组分决定。
Nanoparticles, spherical particles with diameters less than 100 nm, are promising theranostic devices for noninvasive diagnosis and therapy. In this study, nanoparticles composed of polyethylene glycol and silica were prepared, and their migration behavior was examined using capillary electrophoresis. The effects of the sodium dodecyl sulfate concentration in the electrolyte, the nanoparticle size, and the encapsulated molecule on the migration were examined. The addition of sodium dodecyl sulfate into the electrolyte had a significant effect on the electrophoretic mobility of polyethylene glycol nanoparticles, but a small effect on that of silica nanoparticles. As for the size effect, the mobility became a little faster for smaller nanoparticle sizes for both polyethylene glycol and silica nanoparticles. The encapsulated molecule affected the mobility of the nanoparticles through interactions between the encapsulated molecules and sodium dodecyl sulfate. We propose that the large effect of sodium dodecyl sulfate on the migration of the polyethylene glycol nanoparticles was due to the large spaces within the nanoparticles. These results indicate that nanoparticle migration is mainly determined by the nanoparticle components.