The Effect of Cod Liver Oil and Corn Oil on Platelets and Vessel Wall in Man
The Effect of Cod Liver Oil and Corn Oil on Platelets and Vessel Wall in Man
复制标题
鱼肝油和玉米油对人体血小板和血管壁的影响
DOI：
10.1055/s-0038-1653428
复制
发表时间：
1981
影响因子：
6.7
通讯作者：
A. Nordøy
中科院分区：
文献类型：
--
作者：
J. Brox;J. Killie;S. Gunnes;A. Nordøy
在一项交叉研究中，10名普通饮食的健康男性受试者每天给予25 ml鱼肝油（CLO）或玉米油（CO）的膳食补充剂，为期6周。观察到血浆总脂肪酸组成发生显著变化。主要的血小板磷脂组分也发生了显着变化，特别是CLO与二十碳五烯酸（EPA）：花生四烯酸（AA）的比例增加。两种补充剂都能减少胶原诱导的血小板聚集和TXB 2的产生，其中CLO作用最强。静脉组织中未发现抗聚集物质或6-keto-PcF 1 α的自发释放，前列腺素代谢产物（E和F系列）的总尿排泄量保持不变。
Summary Ten healthy male subjects on an ordinary diet were given daily dietary supplement of 25 ml cod liver oil (CLO) or corn oil (CO) for periods of 6 weeks in a crossover study. Significant changes were observed in the plasma total fatty acid composition. The main platelet phospholipids fractions were also significantly altered, particularly by CLO with an increase of the eicosapentaenoic acid (EPA): arachidonic acid (AA) ratio. Both supplements reduced collagen induced platelet aggregation and TXB2 production, with CLO as the most potent one. No spontaneous release of an antiaggregatory substance or 6-keto-PcF1α from vein tissues were found, and the total urinary excretion of prostaglandin metabolites (E and F series) remained unchanged.