NA-K-ATPASE IN NEPHRON SEGMENTS OF RATS DEVELOPING SPONTANEOUS HYPERTENSION
NA-K-ATPASE IN NEPHRON SEGMENTS OF RATS DEVELOPING SPONTANEOUS HYPERTENSION
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DOI：
10.1152/ajprenal.1985.249.6.f863
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发表时间：
1985-12-01
影响因子：
--
通讯作者：
MCARDLE, S
中科院分区：
文献类型：
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作者：
GARG, LC;NARANG, N;MCARDLE, S
本研究测定了5周龄和12周龄自发性高血压大鼠（SHR）和年龄匹配的Wistar-Kyoto（WKY）对照组7个特定肾单位节段的Na-K-ATP酶活性。5周龄SHR近曲小管（PCT）和近直小管（PST）酶活性显著高于WKY。然而，5周龄SHR的髓质粗升支（MTAL）、皮质粗升支（CTAL）和远曲小管（DCT）的Na-K-ATP酶活性显著低于WKY。12周龄SHR和WKY的PCT、PST、MTAL、CTAL和DCT酶活性无显著差异。此外，5和12周龄SHR和年龄匹配的WKY集合管段的Na-K-ATP酶活性无显著差异。5周龄SHR的PCT、PST、MTAL、CTAL和DCT中的Na-K-ATP酶活性异常模式在该品系高血压产生中的可能作用尚待确定。
Na-K-ATPase activity was determined in seven specific nephron segments of 5- and 12-wk-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto (WKY) controls. The enzyme activity in proximal convoluted tubule (PCT) and proximal straight tubule (PST) was significantly higher in 5-wk-old SHR than in WKY. However, Na-K-ATPase activity in medullary thick ascending limb (MTAL), cortical thick ascending limb (CTAL), and distal convoluted tubule (DCT) was significantly lower in 5-wk-old SHR than in WKY. There were no significant differences in the enzyme activity in PCT, PST, MTAL, CTAL, and DCT in 12-wk-old SHR and WKY. Furthermore, there were no significant differences in Na-K-ATPase activity in collecting duct segments of 5- or 12-wk-old SHR and age-matched WKY. The possible role of the abnormal pattern of Na-K-ATPase activity in PCT, PST, MTAL, CTAL, and DCT in 5-wk-old SHR in generation of hypertension in this strain remains to be determined.