Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats.
Transplanted neural stem cells modulate regulatory T, γδ T cells and corresponding cytokines after intracerebral hemorrhage in rats.
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DOI：
10.3390/ijms15034431
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发表时间：
2014-03-13
影响因子：
5.6
通讯作者：
ZhuGe QC
中科院分区：
文献类型：
--
作者：
Gao L;Lu Q;Huang LJ;Ruan LH;Yang JJ;Huang WL;ZhuGe WS;Zhang YL;Fu B;Jin KL;ZhuGe QC
免疫系统，特别是T淋巴细胞和细胞因子，与脑出血（ICH）后脑损伤的进展有关。尽管研究表明，移植神经干细胞（NSCs）可以保护中枢神经系统（CNS）免受炎症损伤，但它们对T淋巴细胞亚群及其相应的细胞因子的影响在很大程度上尚未被探索。本实验采用脑出血大鼠，脑出血后3小时脑内注射NSCs。流式细胞术分析了脑和外周血中T细胞亚群的分布。我们发现，与对照组相比，脑和外周血中的调节性T细胞（Treg）增加，但γδT细胞（γδT细胞）减少，抗炎细胞因子（IL-4、IL-10和TGF-β）增加，促炎细胞因子（IL-6和IFN-γ）减少。我们的数据表明，移植的NSCs通过调节Treg和γδT细胞的浸润以及抗炎和促炎细胞因子的释放来保护脑出血后的脑损伤。
The immune system, particularly T lymphocytes and cytokines, has been implicated in the progression of brain injury after intracerebral hemorrhage (ICH). Although studies have shown that transplanted neural stem cells (NSCs) protect the central nervous system (CNS) from inflammatory damage, their effects on subpopulations of T lymphocytes and their corresponding cytokines are largely unexplored. Here, rats were subjected to ICH and NSCs were intracerebrally injected at 3 h after ICH. The profiles of subpopulations of T cells in the brain and peripheral blood were analyzed by flow cytometry. We found that regulatory T (Treg) cells in the brain and peripheral blood were increased, but γδT cells (gamma delta T cells) were decreased, along with increased anti-inflammatory cytokines (IL-4, IL-10 and TGF-β) and decreased pro-inflammatory cytokines (IL-6, and IFN-γ), compared to the vehicle-treated control. Our data suggest that transplanted NSCs protect brain injury after ICH via modulation of Treg and γδT cell infiltration and anti- and pro-inflammatory cytokine release.
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影响因子：
82.9
作者：
Liesz, Arthur;Suri-Payer, Elisabeth;Veltkamp, Roland
通讯作者：
Veltkamp, Roland
DOI：
10.1073/pnas.0404474101
发表时间：
2004-08-10
影响因子：
11.1
作者：
Kelly, S;Bliss, TM;Steinberg, GK
通讯作者：
Steinberg, GK
影响因子：
8.3
作者：
Gelderblom, Mathias;Leypoldt, Frank;Magnus, Tim
通讯作者：
Magnus, Tim
影响因子：
168.9
作者：
Qureshi, Adnan I.;Mendelow, A. David;Hanley, Daniel F.
通讯作者：
Hanley, Daniel F.
DOI：
10.1084/jem.20021098
发表时间：
2003-09-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Prass K;Meisel C;Höflich C;Braun J;Halle E;Wolf T;Ruscher K;Victorov IV;Priller J;Dirnagl U;Volk HD;Meisel A
通讯作者：
Meisel A