Small animal PET imaging
Small animal PET imaging
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DOI：
10.1093/ilar.49.1.54
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发表时间：
2008-01-01
期刊：
影响因子：
2.5
通讯作者：
Receveur, Timothy
中科院分区：
文献类型：
--
作者：
Hutchins, Gary D.;Miller, Michael A.;Receveur, Timothy
正电子发射断层扫描（PET）是一种重要的研究和临床分子成像方式。尽管人类和啮齿动物之间的尺寸差异给PET成像在小动物中的应用带来了巨大的挑战，但过去几年的技术进步已经使这种成像模式能够转化为临床前应用。在这篇文章中，我们讨论了PET仪器和放射性药物的基本原理，并检查负责小动物PET系统的定性和定量成像能力的关键因素。我们描述了PET显像剂必须满足的标准，并提供了小动物PET成像的例子，让读者对这种不断发展的技术的能力和局限性有一个广泛的视角。PET成像未来发展的一个关键驱动力是用正电子发射放射性核素标记的分子成像探针的可用性。小动物和人类PET的强大转化科学潜力有望大大提高我们对人类疾病的理解。使用成像剂作为直接或替代生物标志物评估分子和功能过程将最终能够表征个体患者中的疾病表达，从而促进定制的治疗计划，可以监测其在每个受试者中的有效性。
Positron emission tomography (PET) is well established as an important research and clinical molecular imaging modality. Although the size differences between humans and rodents create formidable challenges for the application of PET imaging in small animals, advances in technology over the past several years have enabled the translation of this imaging modality to preclinical applications. In this article we discuss the basic principles of PET instrumentation and radiopharmaceuticals, and examine the key factors responsible for the qualitative and quantitative imaging capabilities of small animal PET systems. We describe the criteria that PET imaging agents must meet, and provide examples of small animal PET imaging to give the reader a broad perspective on the capabilities and limitations of this evolving technology. A crucial driver for future advances in PET imaging is the availability of molecular imaging probes labeled with positron-emitting radionuclides. The strong translational science potential of small animal and human PET holds great promise to dramatically advance our understanding of human disease. The assessment of molecular and functional processes using imaging agents as either direct or surrogate biomarkers will ultimately enable the characterization of disease expression in individual patients and thus facilitate tailored treatment plans that can be monitored for their effectiveness in each subject.