24p3 in differentiation of myeloid cells.
24p3 in differentiation of myeloid cells.
复制标题
24p3 在骨髓细胞分化中的作用。
DOI：
10.1002/jcp.20400
复制
发表时间：
2005
影响因子：
5.6
通讯作者：
Baserga,Renato
中科院分区：
文献类型：
--
作者：
Liu,Mingli;Prisco,Marco;Drakas,Robert;Searles,David;Baserga,Renato
24p3 是一种分泌性脂质运载蛋白，与血细胞的凋亡、增殖和中性粒细胞谱系有多种关系。我们研究了胰岛素样生长因子 1 (IGF-1) 和粒细胞集落模拟因子 (G-CSF) 诱导分化的骨髓细胞系中 24p3 mRNA 和蛋白的表达。这两种生长因子都会导致骨髓细胞分化为粒细胞，并诱导 24p3 蛋白和 mRNA 表达显着增加。 mRNA 尤其在用 IGF-1 或 G-CSF 诱导细胞后早期出现，此时细胞仍在增殖且形态上未分化。 24p3 可以被认为是粒细胞分化的早期标志物。 © 2005 Wiley-Liss, Inc.
24p3 is a secreted lipocalin that has been variously related to apoptosis, proliferation, and the neutrophil lineage of blood cells. We have investigated the expression of 24p3 mRNA and protein in myeloid cell lines induced to differentiate by insulin‐like growth factor 1 (IGF‐1) and the granulocytic‐colony simulating factor (G‐CSF). Both these growth factors, which cause myeloid cells to differentiate into granulocytes, induced a marked increase in the expression of both 24p3 protein and mRNA. The mRNA especially appeared early after the cells were induced with either IGF‐1 or G‐CSF, at a time when the cells were still proliferating and are morphologically undifferentiated. 24p3 can be considered an early marker of granulocytic differentiation. © 2005 Wiley‐Liss, Inc.