Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure.
Coagulation-induced resistance to fluid flow in small-diameter vascular grafts and graft mimics measured by purging pressure.
复制标题
通过冲洗压力测量小直径血管移植物和移植物模拟物中凝血引起的流体流动阻力。
DOI：
10.1002/jbm.b.32954
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Reichert,WilliamM
中科院分区：
文献类型：
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作者：
Nichols,MichaelD;Choudhary,Rewa;Kodali,Santhisri;Reichert,WilliamM
在本研究中，通过测量从管腔中清除凝块所需的上游压力，对小直径非渗透性Tygon管和渗透性膨胀型聚四氟乙烯（ePTFE）血管移植物中的凝血诱导流动阻力进行了表征。使用以恒定速率压缩管内容物的封闭系统监测该吹扫压力。压力系统使用甘油系列进行了验证，该甘油系列具有明确定义的粘度和精确控制的可用于流动的横截面积减少。然后使用该系统地探测上游压力积聚，如纤维蛋白胶、富血小板血浆（PRP）或全血在小直径Tygon管和/或ePTFE移植物中凝固。Tygon和ePTFE管中的纤维蛋白胶、PRP和全血的最大清洗压力随着凝块成熟度的增加而升高。尽管在非渗透性Tygon管中快速溶解的纤维蛋白胶产生了高度一致的净化曲线，但PRP和全血的凝血时间显著更长且变化更大，以及ePTFE移植物的孔隙率显著降低了净化曲线的一致性。© 2013威利期刊公司. J Biomed Mater Res Part B：Appl Biomater，101 B：1367-1376，2013.
In this study, the coagulation‐induced resistance to flow in small‐diameter nonpermeable Tygon tubes and permeable expanded polytetrafluoroethylene (ePTFE) vascular grafts was characterized by measuring the upstream pressure needed to purge the coagulum from the tube lumen. This purging pressure was monitored using a closed system that compressed the contents of the tubes at a constant rate. The pressure system was validated using a glycerin series with well‐defined viscosities and precisely controlled reductions in cross‐sectional area available for flow. This system was then used to systematically probe the upstream pressure buildup as fibrin glue, platelet‐rich plasma (PRP) or whole blood coagulated in small‐diameter Tygon tubing and or ePTFE grafts. The maximum purging pressures rose with increased clot maturity for fibrin glue, PRP, and whole blood in both Tygon and ePTFE tubes. Although the rapidly coagulating fibrin glue in nonpermeable Tygon tubing yielded highly consistent purging curves, the significantly longer and more variable clotting times of PRP and whole blood, and the porosity of ePTFE grafts, significantly diminished the consistency of the purging curves. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 101B: 1367–1376, 2013.