Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
Acute Inflammation Initiates the Regenerative Response in the Adult Zebrafish Brain
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DOI：
10.1126/science.1228773
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发表时间：
2012-12-07
期刊：
影响因子：
56.9
通讯作者：
Brand, Michael
中科院分区：
文献类型：
--
作者：
Kyritsis, Nikos;Kizil, Caghan;Brand, Michael
斑马鱼在受伤后会再生其大脑，因此是研究再生神经发生机制的有用模式生物，这在哺乳动物中很少表现出来。然而，在鱼类中启动这种再生反应的信号机制尚不清楚。通过脑室微量注射免疫原颗粒和免疫抑制试验，我们证明了炎症是促进神经前体细胞增殖和随后的神经再生的必要条件和充分条件，它通过激活创伤后可以观察到的损伤诱导的分子程序来实现。我们还发现半胱氨酰白三烯信号是成年斑马鱼大脑再生过程中炎症的重要组成部分。因此，我们的结果表明，与哺乳动物不同，在斑马鱼中，炎症是中枢神经系统神经元再生的积极调节因素。
The zebrafish regenerates its brain after injury and hence is a useful model organism to study the mechanisms enabling regenerative neurogenesis, which is poorly manifested in mammals. Yet the signaling mechanisms initiating such a regenerative response in fish are unknown. Using cerebroventricular microinjection of immunogenic particles and immunosuppression assays, we showed that inflammation is required and sufficient for enhancing the proliferation of neural progenitors and subsequent neurogenesis by activating injury-induced molecular programs that can be observed after traumatic brain injury. We also identified cysteinyl leukotriene signaling as an essential component of inflammation in the regenerative process of the adult zebrafish brain. Thus, our results demonstrate that in zebrafish, in contrast to mammals, inflammation is a positive regulator of neuronal regeneration in the central nervous system.