Feasibility of breast-conserving, therapy for macroscopically multiple ipsilateral breast cancer
Feasibility of breast-conserving, therapy for macroscopically multiple ipsilateral breast cancer
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DOI：
10.1016/j.ijrobp.2003.09.088
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发表时间：
2004-05-01
影响因子：
7
通讯作者：
Kodama, H
中科院分区：
文献类型：
--
作者：
Okumura, S;Mitsumori, M;Kodama, H
目的：宏观多发性同侧乳腺癌（MMIBC）通常被认为是保乳治疗（BCT）的禁忌症。报道了BCT在MMIBC中的应用结果，并对其可行性进行了讨论。方法与材料：1993年7月至1999年2月，对34例MMIBC患者行BCT检查。将这些患者的局部控制、无病生存和美容结果与单一疾病患者进行比较。结果：34例MMIBC患者经广泛切除后，21例（62%）患者手术切缘紧密，发生率明显高于单发病变患者。然而，增压辐照场的大小并没有明显增加。在中位随访98个月时，与单一病变患者相比，在局部控制、无病生存或美容结果方面没有统计学上的显著差异。结论：尽管MMIBC患者在BCT后经常出现手术切缘闭合，但只要准确检测到手术切缘闭合并采用适当的放射技术治疗，它可以成为这些患者的一种治疗选择。(C) 2004爱思唯尔公司
Purpose: Macroscopically multiple ipsilateral breast cancer (MMIBC) is generally considered a contraindication for breast-conserving therapy (BCT). The result of BCT for MMIBC is reported and the feasibility discussed.Methods and Materials: Between July 1993 and February 1999, 34 patients with MMIBC underwent BCT at our clinic. The local control, disease-free survival, and cosmetic results in these patients were compared with those of patients with single disease.Results: After wide excision, 21 (62%) of 34 patients with MMIBC had a close surgical margin and the rate was significantly greater than that of patients with a single lesion. However, the size of the boost irradiation field was not significantly increased. At a median follow-up of 98 months, no statistically significant difference was Doted in local control, disease-free survival, or cosmetic result compared with patients with a single lesion.Conclusion: Although patients with MMIBC frequently had close surgical margins after BCT, it can be a treatment option for these patients as long as the close surgical margin is accurately detected and treated with an appropriate radiation technique. (C) 2004 Elsevier Inc.