A neurophysiological profile in Parkinson’s disease with mild cognitive impairment and dementia in China
A neurophysiological profile in Parkinson’s disease with mild cognitive impairment and dementia in China
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DOI：
10.1016/j.jocn.2014.11.030
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发表时间：
2015-06
影响因子：
2
通讯作者：
Ya-qin Wang;B. Tang;Xinxiang Yan;Zhiheng Chen;Qian Xu;Zhenhua Liu;Kai Li;Kai Wang;Ji-feng Guo
中科院分区：
文献类型：
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作者：
Ya-qin Wang;B. Tang;Xinxiang Yan;Zhiheng Chen;Qian Xu;Zhenhua Liu;Kai Li;Kai Wang;Ji-feng Guo
轻度认知障碍 (MCI) 和痴呆 (D) 是帕金森病 (PD) 的常见特征，但使用的标准却截然不同。我们对中国帕金森病患者的患病率和认知状况的了解仍然有限。为了确定中国汉族帕金森病患者认知功能障碍的频率和模式，并确定认知功能障碍的危险因素，我们对 330 名帕金森病患者和 163 名健康对照者进行了一项横断面研究。评估了五个认知领域（执行功能、注意力、实践和视觉空间功能、记忆和语言）和情绪/行为。根据运动障碍协会工作组共识标准，高达 29.1% 的 PD 患者被归类为 PD-MCI，32.1% 被归类为 PD-D。一系列认知领域都会出现障碍，其中以执行障碍为主。健康对照者在执行功能和注意力任务方面也优于认知能力保留的帕金森病患者。 Logistic回归表明PD-MCI可能是通过较低的教育水平和冷漠来预测的。此外，发病较晚、病程较长、运动症状较严重和神经精神库存评分较高与从 PD-MCI 更快过渡到 PD-D 相关。这些发现表明所有帕金森病患者都应接受常规认知筛查。对于高危患者，早期识别和治疗干预势在必行。
Mild cognitive impairment (MCI) and dementia (D) are frequent features of Parkinson’s disease (PD) but widely disparate criteria have been used. Our understanding of the prevalence and cognitive profile of Chinese PD patients remains limited. In order to determine the frequency and pattern of cognitive dysfunction and identify risk factors for cognitive dysfunction in the Chinese Han PD population we performed a cross-sectional study in a cohort of 330 PD patients and 163 healthy controls. Five cognitive domains (executive function, attention, praxis and visuospatial function, memory, and language) and mood/behavior were evaluated. According to the Movement Disorder Society Task Force consensus criteria, up to 29.1% of PD patients were classified as PD-MCI and 32.1% as PD-D. Impairments occur in a range of cognitive domains with dysexecutive profile predominating. Healthy controls also outperformed cognitively preserved PD patients in tasks of executive function and attention. Logistic regression indicated that PD-MCI may be predicted by lower educational level and apathy. Additionally, later disease onset, longer disease duration, more severe motor symptoms and higher neuropsychiatric inventory score were associated with a faster transition from PD-MCI to PD-D. These findings suggest that all PD patients should undergo routine cognitive screening. For high-risk patients early recognition and therapeutic intervention is imperative.