Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Likelihood of Having Depressive Symptoms among Japanese Workers
Low Serum 25-Hydroxyvitamin D Concentrations Are Associated with Increased Likelihood of Having Depressive Symptoms among Japanese Workers
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DOI：
10.3945/jn.114.204115
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发表时间：
2015-03-01
影响因子：
4.2
通讯作者：
Nanri, Akiko
中科院分区：
文献类型：
--
作者：
Mizoue, Tetsuya;Kochi, Takeshi;Nanri, Akiko
背景：越来越多的证据表明维生素D对情绪障碍有保护作用，但在工作人群中的流行病学研究很少。目的：我们横断面调查了日本工人中血清维生素D状况与抑郁症状的关系。方法：调查对象为1786名接受健康体检并参加营养与健康调查的19-69岁的员工(9%为女性)。采用竞争性蛋白结合法测定血清25-羟基维生素D[25(OH)D]浓度。采用流行病学研究中心抑郁量表(CES-D)评定抑郁症状。结果：总体而言，92%的研究参与者的维生素D水平低于最佳水平[25(OH)D<；30µg/L]。抑郁症状与25(OH)D浓度呈负相关，25(OH)D浓度为20~29µg/L和30µg/L的抑郁症状分别为0.75(0.59，0.95)和0.66(0.41，1.06)。在进一步调整休闲体育活动和倒班工作(与光引发的维生素D产生密切相关的因素)后，最高类别的25(OH)D的OR(95%CI)为0.70(0.43，1.14)。根据限制性三次样条法回归，25(OH)D与抑郁症状之间呈线性关系。结论：在表面健康的工人中，循环中维生素D浓度较低与抑郁症状的可能性增加有关。
Background: Accumulating evidence suggests a protective role of vitamin D against mood disorders; however, epidemiologic studies are scarce in working populations.Objective: We investigated cross-sectionally the association of serum vitamin D status and depressive symptoms among Japanese workers.Methods: Participants were 1786 employees (9% women), aged 19-69 y, who received health check-ups and participated in a nutrition and health survey. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured with the use of a competitive protein binding assay. Depressive symptoms were assessed by using the Center for Epidemiologic Studies Depression (CES-D) scale. Logistic regression was used to estimate ORs with adjustment for potential confounding variables including dietary factors.Results: Overall, 92% of study participants had suboptimal vitamin D status [25(OH)D < 30 mu g/L]. Depressive symptoms were inversely associated with 25(OH) D. Compared with those with a 25(OH)D concentration of = 16) were 0.75 (0.59, 0.95) and 0.66 (0.41, 1.06) for those with a 25(OH) D concentration of 20-29 mu g/L and >= 30 mu g/L, respectively (P-trend = 0.01). After further adjustment for leisure-time physical activity and shift work (factors closely related to photo-initiated vitamin D production), the OR (95% CI) for the highest category of 25(OH)D was 0.70 (0.43, 1.14). The association between 25(OH)D and depressive symptoms appears to be linear, according to restricted cubic spline regression.Conclusion: Results suggest that lower concentrations of circulating vitamin D are associated with increased likelihood of having depressive symptoms among apparently healthy workers.