Cocaine does not produce reward in absence of dopamine transporter inhibition.
Cocaine does not produce reward in absence of dopamine transporter inhibition.
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DOI：
10.1097/wnr.0b013e32831b9ce4
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发表时间：
2009-01-07
期刊：
影响因子：
1.7
通讯作者：
Gu HH
中科院分区：
文献类型：
--
作者：
Tilley MR;O'Neill B;Han DD;Gu HH
以前，我们报告说，敲入小鼠与可卡因不敏感的多巴胺转运蛋白（DAT-CI小鼠）不经历可卡因奖励，作为测量条件性位置偏好（CPP）。这一结论受到了仔细审查，因为一些转基因小鼠在窄剂量范围内显示可卡因诱导的CPP，即在约10 mg/kg的剂量下有反应，但在5和20 mg/kg时没有反应，这是我们在DAT-CI小鼠中测试的剂量。这些结果增加了我们错过可卡因反应的最佳剂量的可能性。在这里，我们报告说，可卡因不产生奖励在DAT-CI小鼠在低，中，高剂量，包括10毫克/公斤。这项研究加强了我们的结论，DAT抑制所需的可卡因奖励与功能多巴胺能系统的小鼠。
Previously we reported that knock-in mice with a cocaine-insensitive dopamine transporter (DAT-CI mice) do not experience cocaine reward, as measured by conditioned place-preference (CPP). This conclusion has come under scrutiny because some genetically modified mice show cocaine-induced CPP in a narrow dose range, i.e. responding at doses around 10 mg/kg, but not at 5 and 20 mg/kg, the doses we tested in DAT-CI mice. These results raise the possibility that we have missed the optimal dose for cocaine response. Here we report that cocaine does not produce reward in DAT-CI mice at low, moderate, and high doses, including 10 mg/kg. This study strengthens our conclusion that DAT inhibition is required for cocaine reward in mice with a functional dopaminergic system.