Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam
Ligand-promoted ruthenium-catalyzed meta C-H chlorination of arenes using N-chloro-2,10-camphorsultam
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DOI：
10.1039/c8cc03195a
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发表时间：
2018-06-14
影响因子：
4.9
通讯作者：
Zhang, Ao
中科院分区：
文献类型：
--
作者：
Fan, Zhoulong;Lu, Heng;Zhang, Ao
通过Ru(0)催化的邻位金属化策略，建立了一个实用的元碳氢氯化方案。使用n -氯-2,10-樟脑丹作为氯化剂对当前反应的成功至关重要，n -杂环碳（NHC）配体可以显著提高催化转化的反应活性。机理研究表明，C-Ru键的邻位氯化反应可能参与了一个不寻常的邻位C-H钌化接力过程。
A practical meta C-H chlorination protocol is established via a Ru(0)-catalyzed ortho-metalation strategy. The use of N-chloro-2,10-camphorsultam as a new chlorinating agent is crucial for the success of the current reaction and an N-heterocyclic carbene (NHC) ligand could significantly enhance the reactivity of the catalytic transformation. The mechanistic studies reveal that an unusual ortho C-H ruthenation relay process with ortho chlorination of the C-Ru bond is probably involved.