Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
Low free testosterone concentration as a potentially treatable cause of depressive symptoms in older men
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DOI：
10.1001/archgenpsychiatry.2007.33
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发表时间：
2008-03-01
影响因子：
--
通讯作者：
Flicker, Leon
中科院分区：
文献类型：
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作者：
Almeida, Osvaldo P.;Yeap, Bu B.;Flicker, Leon
内容：性腺激素的血清浓度与各种健康指标有关，但目前尚不清楚它们与情绪的关系是否受到并发身体疾病的混淆。目的：确定老年男性血清睾酮浓度与情绪之间的关系是否独立于身体并发症。设计：横断面研究。设置：西澳大利亚州珀斯社区。参与者：主要结果测量：我们使用15项老年抑郁量表（GDS-15）评估抑郁情绪。具有临床意义的抑郁症被先验地定义为GDS-15评分为7分或更高。身体健康进行了评估，使用加权的Charlson指数和身体成分的36项简表健康Survey.Results：在3987名男性纳入研究，203（5.1%，95%的置信区间[CI]，4.4%-5.8%）有抑郁症。抑郁症患者的总睾酮和游离睾酮浓度显著低于非抑郁症男性（P
Context: Serum concentrations of gonadal hormones have been associated with various measures of wellbeing, but it is unclear whether their association with mood is confounded by concurrent physical morbidity.Objective: To determine whether the association between serum testosterone concentration and mood in older men is independent of physical comorbidity.Design: Cross-sectional study.Setting: Community of Perth, Western Australia.Participants: A community sample of men aged 71 to 89 years.Main Outcome Measures: We used the 15-item Geriatric Depression Scale ( GDS-15) to assess depressed mood. Clinically significant depression was defined a priori as a GDS-15 score of 7 or greater. Physical health was assessed using the weighted Charlson index and the Physical Component Summary score of the 36-Item Short Form Health Survey.Results: Of 3987 men included in the study, 203 ( 5.1%; 95% confidence interval [CI], 4.4%-5.8%) had depression. Participants with depression had significantly lower total and free testosterone concentrations than nondepressed men ( P