Bacterial endotoxin (lipopolysaccharide) stimulates the rate of iron oxidation
Bacterial endotoxin (lipopolysaccharide) stimulates the rate of iron oxidation
复制标题
细菌内毒素（脂多糖）刺激铁氧化速率
DOI：
10.1177/09680519000060040701
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
J. Levin
中科院分区：
文献类型：
--
作者：
R. Roth;S. Panter;A. Zegna;J. Levin
Bacterial endotoxin (lipopolysaccharide) has affinity for a number of cations, including iron. Previous investigations have demonstrated that lipopolysaccharide can affect the oxidation rate of iron; heme-bound ferrous iron in hemoglobin is oxidized to ferric iron when hemoglobin binds lipopolysaccharide. In the present study, we directly examined the interaction between lipopolysaccharide and iron. Lipopolysaccharide caused a concentration-dependent increase in the rate of iron oxidation, with up to a 23-fold increase in oxidation in the presence of 200 µg/ml Escherichia coli lipopolysaccharide. This effect was seen both with several carbohydrate-rich smooth lipopolysaccharides and also with carbohydrate-poor rough lipopolysaccharide. Extensively deacylated rough lipopolysaccharide had no effect, suggesting a role of the fatty acid components of lipopolysaccharide in this process. Purified lipid A produced inconsistent results: some preparations stimulated iron oxidation and others did not. A series of sugars, starches and a preparation of purified O-chain polysaccharide (the carbohydrate portion of the lipopolysaccharide macromolecule) had no effect on the rate of iron oxidation, whereas phospholipid-enriched brain tissue extracts (similar to the lipid A component of lipopolysaccharide) stimulated oxidation. We conclude that the lipid moiety of bacterial lipopolysaccharide is responsible for the stimulation of iron oxidation. This process may contribute to the ability of lipopolysaccharide to cause oxidation of heme-bound iron in hemoglobin.
影响因子：
2.9
作者：
KACA, W;ROTH, RI;LEVIN, J
通讯作者：
LEVIN, J
血红蛋白可增强内皮细胞对细菌内毒素的反应而产生组织因子。
影响因子：
20.3
作者：
Roth,RI
通讯作者：
Roth,RI
血红蛋白是一种新发现的脂多糖 (LPS) 结合蛋白，可增强 LPS 的生物活性。
DOI：
--
发表时间：
1994
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Kaca,W;Roth,RI;Levin,J
通讯作者：
Levin,J