Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study.
Bioabsorbable self-retaining PLA/nano-sized β-TCP cervical spine interbody fusion cage in goat models: an in vivo study.
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山羊模型中生物可吸收自固位 PLA/纳米 β-TCP 颈椎椎间融合器：一项体内研究
DOI：
10.2147/ijn.s132041
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发表时间：
2017
影响因子：
8
通讯作者：
Dong J
中科院分区：
文献类型：
--
作者：
Cao L;Chen Q;Jiang LB;Yin XF;Bian C;Wang HR;Ma YQ;Li XQ;Li XL;Dong J
这是一项动物实验研究。本研究的目的是比较新型聚乳酸/纳米β-磷酸三钙（PLA/nβ-TCP）生物可吸收自固位颈椎融合器（BCFC）与自体骨移植物和聚醚醚酮（PEEK）融合器的颈椎前路椎间盘切除术和椎间融合术。尽管PLA颈椎融合器与传统材料相比具有潜在优势，但由于其不良反应（如缺乏骨传导性和植入物周围骨质溶解），目前尚未常规用于脊柱手术。本研究涉及由PLA/nβ-TCP制造生物可吸收融合器，然后将其用作山羊颈椎融合模型上的颈椎前路椎间盘切除融合术（ACDF）器械。18只山羊接受了C3/C4椎间盘切除术，并根据以下方法随机分为3组：A组（n=6），自体植骨; B组（n=6），PEEK椎间融合器填充自体植骨; C组（n=6），BCFC填充自体髂骨。术前、术后和术后1、4、8和12周进行X线摄影。同时测量椎间隙高度（DSH）。12周后，收集融合节段，并通过功能性X线片、生物力学测试和组织学分析进行评价。在12周内，BCFC和PEEK椎间融合器组的DSH值显著高于植骨组。此外，BCFC组的轴向旋转活动度显著低于自体植骨和PEEK椎间融合器组。组织学评价显示，BCFC组的椎间骨体积/总体积比增加，椎间融合优于其他组。在体内单节段ACDF模型中，BCFC器械的结果优于自体植骨和PEEK融合器。该器械可能是当前PEEK椎间融合器的潜在替代品。
This is an experimental animal study. The objective of this study was to compare an anterior cervical discectomy and interbody fusion of a novel polylactide/nano-sized β-tricalcium phosphate (PLA/nβ-TCP) bioabsorbable self-retaining cervical fusion cage (BCFC) with an autologous bone graft and polyetheretherketone (PEEK) cages. Although PLA cervical cages have potential advantages compared with traditional materials, they are not currently routinely used in spine surgery because of undesirable effects such as the lack of osteoconductivity and osteolysis around the implant. This study involved the manufacturing of a bioabsorbable cage from PLA/nβ-TCP that was then used as a device for anterior cervical discectomy and fusion (ACDF) on a goat cervical spine fusion model. Eighteen goats underwent C3/C4 discectomy and were randomly divided into three groups based on the following methods: Group A (n=6), an autologous bone graft; Group B (n=6), PEEK cage filled with an autologous graft; and Group C (n=6), BCFC filled with an autologous iliac bone. Radiography was performed preoperatively and postoperatively and at 1, 4, 8, and 12 weeks after the operation. Disc space height (DSH) was measured at the same time. After 12 weeks, the fused segments were harvested and evaluated with functional radiographic views, biomechanical testing, and histological analyses. Over a 12-week period, the BCFC and PEEK cage groups exhibited significantly higher DSH values than the bone graft group. Additionally, the BCFC group yielded a significantly lower range of motion in axial rotation than both the autologous bone graft and PEEK cage groups. A histologic evaluation revealed an increased intervertebral bone volume/total volume ratio and better interbody fusion in the BCFC group than in the other groups. The BCFC device exhibited better results than the autologous bone graft and PEEK cages in single-level ACDF models in vivo. This device may be a potential alternative to the current PEEK cages.