DNA alkylation properties of yatakemycin
DNA alkylation properties of yatakemycin
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DOI：
10.1021/ja035984h
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发表时间：
2003-09-10
影响因子：
15
通讯作者：
Boger, DL
中科院分区：
文献类型：
--
作者：
Parrish, JP;Kastrinsky, DB;Boger, DL
Yatakemycin代表了一类天然存在的抗肿瘤化合物中最新和现在最有效的成员，包括CC-1065和倍癌霉素，其生物学特性来自特征性DNA烷基化反应。在此，第一次描述的Yatakemycin DNA烷基化的性能进行了详细说明，构成了第一个这样的研究自然发生的“三明治”成员这一类。因此，事件，序列的选择性，相对速率和效率，和可逆性的DNA烷基化反应的矢田霉素进行了描述。
Yatakemycin represents the newest and now most potent member of a class of naturally occurring antitumor compounds that includes CC-1065 and the duocarmycins, which derive their biological properties from a characteristic DNA alkylation reaction. Herein, the first description of the yatakemycin DNA alkylation properties is detailed, constituting the first such study of a naturally occurring "sandwiched" member of this class. Thus, the event, sequence selectivity, relative rate and efficiency, and reversibility of the DNA alkylation reaction of yatakemycin are described.