Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing
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DOI：
10.1093/cercor/bhl026
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发表时间：
2007-05-01
期刊：
影响因子：
3.7
通讯作者：
Lesch, Klaus-Peter
中科院分区：
文献类型：
--
作者：
Herrmann, Martin J.;Huter, Theresa;Lesch, Klaus-Peter
先前的研究报道，5-羟色胺转运体（5-HTT）和色氨酸羟化酶-2（TPH 2）基因的功能变体，2个关键的调节因子的多巴胺能信号通路，调节杏仁核激活过程中的情绪处理。我们使用情绪图片处理任务来解决这两个基因变体是否相互调节的问题。具体而言，我们测量事件相关电位（ERP）在被动情绪图片感知任务，集中在ERP的早期后负波（EPN）约240毫秒和慢波开始在315毫秒。我们发现的证据增加神经活动在240毫秒的个人谁携带1或2个副本的低表达的短变异的5-HTT。TPH 2的T变体的携带者也表现出在240 ms时神经活动增加的趋势。此外，我们观察到EPN的两种基因型的加性效应，在携带5-HTT的短变体和TPH 2的T变体的个体中，对情绪刺激的神经活动最高。我们的研究结果表明，5-HTT和TPH 2基因型调节的感觉编码的情感刺激在视觉处理的早期步骤，并揭示了2个基因的加性效应在情绪调节的神经元控制。
Prior studies reported that functional variants of both the serotonin transporter (5-HTT) and tryptophan hydroxylase-2 genes (TPH2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. We addressed the question whether these 2 gene variants modulate each other, using an emotional picture-processing task. Specifically, we measured event-related potentials (ERPs) during a passive emotional picture perception task, focusing on ERPs for the early posterior negativity (EPN) around 240 ms and for the slow wave starting at 315 ms. We found evidence for increased neural activity at 240 ms in individuals who carried 1 or 2 copies of the low-expression short variant of the 5-HTT. Carriers of T variant of the TPH2 also showed a tendency toward increased neural activity at 240 ms. Moreover, we observed an additive effect of both genotypes for EPN, with highest neural activity to emotional stimuli in individuals carrying combination of both short variant of 5-HTT and T variant of TPH2. Our results indicate that both the 5-HTT and the TPH2 genotypes modulate the sensory encoding of affective stimuli during early steps of visual processing and reveal additive effects of 2 genes in the serotonergic control of emotion regulation.