Ovarian reserve in women with a previous history of severe pre-eclampsia
Ovarian reserve in women with a previous history of severe pre-eclampsia
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DOI：
10.1007/s00404-016-4193-8
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发表时间：
2017-01-01
影响因子：
2.6
通讯作者：
Acharya, Ganesh
中科院分区：
文献类型：
--
作者：
Bhide, Priya;Vartun, Ase;Acharya, Ganesh
严重的先兆子痫会影响产妇健康，并造成长期后果。据推测，在着床和细胞分化的过程中，老化卵母细胞受精产生的胚胎产生营养外胚层功能障碍，导致胎盘功能障碍。因此，重度子痫前期可能与卵巢储备功能下降有关。本研究的目的是比较重度子痫前期妇女和正常妊娠妇女的卵巢储备和功能的血清标志物，20名重度子痫前期妇女（PE）和20名年龄和体重指数匹配的无并发症妊娠妇女（对照组）被纳入研究。在分娩后6个月至5年的月经周期的卵泡期（第5天）采集空腹血样。分离血清并在-70 ℃冷冻，直至分析抗苗勒管激素（AMH）、总睾酮和游离睾酮（TT）、游离雄激素指数（FAI）、促黄体生成素（LH）和促卵泡激素（FSH）激素以评价卵巢储备和功能。PE组AMH中位数为0.91 ng/mL，对照组为0.72 ng/mL（p = 0.995）。两组间LH（分别为5.65与5.4 IU/L，p = 0.897）和FSH（分别为4.95与5.1 IU/L，p = 0.523）水平无显著差异。然而，与对照组相比，PE组的总TT和游离TT水平以及FAI显著降低（分别为p = 0.017，p = 0.006和p = 0.011）。与无并发症妊娠的妇女相比，有先兆子痫病史的妇女的卵巢储备和功能没有显著改变。
Severe pre-eclampsia affects maternal health with long-term consequences. It is postulated that during the process of implantation and cell differentiation, embryos resulting from the fertilization of ageing oocytes produce malfunctioning trophoectoderm leading to placental dysfunction. Therefore, severe pre-eclampsia may be associated with a decreased ovarian reserve. The objective of this study was to compare serum markers of ovarian reserve and function between women who had severe pre-eclampsia and those who had normal pregnancies.Twenty women who had severe pre-eclampsia (PE) and 20 who had uncomplicated pregnancies (controls) matched for age and body mass index were included in the study. Fasting blood samples were taken during the follicular phase (day 5) of the menstrual cycle 6 months to 5 years after the delivery. Serum was separated and frozen at -70 A degrees C until analyzed for anti-MIillerian hormone (AMH), total and free testosterone (TT), free-androgen index (FAI), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) hormone to evaluate ovarian reserve and function, and the results were compared between two groups.The median AMH was 0.91 ng/mL in PE group compared to 0.72 ng/mL in controls (p = 0.995). No significant differences were found between the two groups in the levels of LH (5.65 vs. 5.4 IU/L, respectively, p = 0.897) and FSH (4.95 vs. 5.1 IU/L, respectively, p = 0.523). However, total and free-TT levels as well as FAI were significantly lower in the PE group compared to controls (p = 0.017, p = 0.006, and p = 0.011, respectively).Ovarian reserve and function are not altered significantly in women with a previous history of pre-eclampsia compared with women who had an uncomplicated pregnancy.