PEGylated GdF3:Fe Nanoparticles as Multimodal T1/T2-Weighted MRI and X-ray CT Imaging Contrast Agents
PEGylated GdF3:Fe Nanoparticles as Multimodal T1/T2-Weighted MRI and X-ray CT Imaging Contrast Agents
复制标题
聚乙二醇化 GdF3:Fe 纳米粒子作为多模态 T1/T2 加权 MRI 和 X 射线 CT 成像造影剂
DOI：
10.1021/acsami.7b04438
复制
发表时间：
2017-06-21
影响因子：
9.5
通讯作者：
Zhang, Hongjie
中科院分区：
文献类型：
--
作者：
Dong, Lile;Zhang, Peng;Zhang, Hongjie
用于多模态成像的造影剂在癌症诊断中具有很高的需求。迄今为止，在一个系统中集成T-1/T-2加权磁共振成像（MRI）和X射线计算机断层扫描（CT）成像功能以获得准确诊断仍然具有挑战性。本研究设计并合成了具有生物相容性的聚乙二醇化GdF 3：Fe纳米粒子（PEG-GdF 3：Fe NPs），作为多功能对比剂，用于有效的T-1/T-2加权MRI和X射线CT多模式成像。由于增强的渗透性和体内滞留效应，静脉注射PEG-GdF 3：Fe NPs后，可以观察到肿瘤病灶中的强T-1对比度、明显的T-2对比度和X射线CT信号。因此，PEG-GdF 3：Fe NPs可用作潜在的多模式造影剂用于癌症诊断。
Contrast agents for multimodal imaging are in high demand for cancer diagnosis. To date, integration of T-1/T-2-weighted magnetic resonance imaging (MRI) and X-ray computed tomography (CT) imaging capabilities in one system to obtain an accurate diagnosis still remains challenging. In this work, biocompatible PEGylated GdF3:Fe nanoparticles (PEG-GdF3:Fe NPs) were reasonable designed and synthesized as multifunctional contrast agents for efficient T-1/T-2-weighted MRI and Xray CT multimodal imaging. Owing to the enhanced permeability and retention effect in vivo, strong T-1 contrast, evident T-2 contrast, and X-ray CT signals in a tumor lesion can be observed after intravenous injection of PEG-GdF3:Fe NPs. Therefore, PEG-GdF3:Fe NPs could be used as potential multimodal contrast agents for cancer diagnosis.