Human interleukin-1β and interleukin-1 receptor antagonist secretion and velocity of tooth movement
Human interleukin-1β and interleukin-1 receptor antagonist secretion and velocity of tooth movement
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DOI：
10.1016/s0003-9969(00)00088-1
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发表时间：
2001-02-01
影响因子：
3
通讯作者：
Petro, TM
中科院分区：
文献类型：
--
作者：
Iwasaki, LR;Haack, JE;Petro, TM
细胞因子IL-1 β和IL-1受体拮抗剂（IL-1 RA）可能在正畸牙齿移动中发挥作用。在这里，在压缩牙周膜（PDL）的力的大小和力的应用领域进行了控制和牙齿移动的速度与龈沟液（GCF）中的IL-1B和IL-1 RA的浓度。七个人接受正畸治疗，包括上颌第一前磨牙拔除和上颌尖牙远中移动（身体回缩）参加了84天的研究。对于每名参与者，施加连续牵开力，使其接受等效PDL应力，其中一只犬为13 kPa，另一只犬为4 kPa。来自实验和对照牙齿的GCF细胞因子浓度相对于GCF中的总蛋白表达，并使用“活性指数”（AI）=实验（IL-1 β/IL-1 RA）/对照（IL-1 β/IL-1 RA）进行比较。结果表明，个体牙齿移动速度与At有关。AI与牙齿移动的相关性从远中（R-d = 0.78）强于从近中（R-m = 0.65）。结果表明，等效力系统产生的细胞因子产生的个体差异，这与犬回缩速度的个体差异。(C)2001爱思唯尔科技有限公司版权所有。
The cytokines interleukin-1 beta (IL-1 beta) and IL-1 receptor antagonist (IL-1RA) probably play a part in orthodontic tooth movement. Here, the force magnitudes and the area of force application in the compressed periodontal ligament (PDL) were controlled and the velocity of tooth movement correlated with concentrations of IL-IB and IL-IRA in the gingival crevicular fluid (GCF). Seven individuals undergoing orthodontic treatment involving maxillary first premolar extractions and distal movement (bodily retraction) of the maxillary canines participated in the 84-day study. For each participant, continuous retraction forces were applied so that they received equivalent PDL stresses of 13 kPa for one canine and 4 kPa for the other. GCF cytokine concentrations from experimental and control teeth were expressed relative to total protein in the GCF and compared using an 'Activity Index' (AI) = Experimental (IL-1 beta /IL-1RA)/Control (IL-1 beta /IL-1RA). The results showed that the velocity of tooth movement in an individual was related to their At. The correlation between AI and tooth movement was stronger from the distal (R-d = 0.78) than from the mesial (R-m = 0.65) of retracted teeth. The results demonstrate that equivalent force systems produce individual differences in cytokine production, which correlate with interindividual differences in the velocity of canine retraction. (C) 2001 Elsevier Science Ltd. All rights reserved.