Plasma tau correlateswith basal forebrain atrophy rates in people at risk for Alzheimer disease
Plasma tau correlateswith basal forebrain atrophy rates in people at risk for Alzheimer disease
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DOI：
10.1212/wnl.0000000000008696
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发表时间：
2020-01-07
期刊：
影响因子：
9.9
通讯作者：
Hampel, Harald
中科院分区：
文献类型：
--
作者：
Cavedo, Enrica;Lista, Simone;Hampel, Harald
目的探讨认知功能正常的阿尔茨海默病(AD)高危老年人血浆总tau(t-tau)和神经细丝轻链(NFL)链蛋白浓度与基础前脑胆碱能系统(BFCS)年变化百分比(APC)之间的关系。参与者接受了血浆t-tau和NFL浓度的基线评估，以及基线和24个月随访的MRI扫描。用线性模型研究血浆NFL和t-tau浓度及其与β-淀粉样蛋白状态和apoE基因的交互作用对BFCS及其前部(Ch1/2)和后部(Ch4)APC的影响。结果基线时血浆t-tau浓度越高，BFCS萎缩率越高(无影响因素模型：n=251，F值=4.6815；p值=0.031)。分区域分析显示，CH1/2(无影响因素模型：n=256，F值=3.9535，p=0.047)和CH4 BFCS扇区(无影响因素模型：n=253，F值=4.9090，p=0.047)的平均预测结果相似。基线NFL、β-淀粉样蛋白负荷和载脂蛋白E
ObjectiveTo investigate whether baseline concentrations of plasma total tau (t-tau) and neurofilament light (NfL) chain proteins are associated with annual percent change (APC) of the basal forebrain cholinergic system (BFCS) in cognitively intact older adults at risk for Alzheimer disease (AD).MethodsThis was a large-scale study of 276 cognitively intact older adults from the monocentric INSIGHT-preAD (Investigation of Alzheimer's Predictors in Subjective Memory Complainers) cohort. Participants underwent baseline assessment of plasma t-tau and NfL concentrations as well as baseline and 24-month follow-up MRI scans. Linear models with and without influential observations (calculated using the Cook distance) were carried out to investigate the effect of plasma NfL and t-tau concentrations, and their interaction effect with beta-amyloid status and APOE genotype, on the APC of the whole BFCS and its anterior (Ch1/2) and posterior (Ch4) subdivisions separately.ResultsHigher plasma t-tau concentrations at baseline were associated with higher BFCS rate of atrophy (model without influencers: n = 251, F value = 4.6815; p value = 0.031). Subregional analyses showed similar results for both the APC of the Ch1/2 (model without influencers: n = 256, F value = 3.9535, p corrected = 0.047) and Ch4 BFCS sectors (model without influencers: n = 253, F value = 4.9090, p corrected = 0.047). Baseline NfL, beta-amyloid load, and APOE