SEQUENCE AND EXPRESSION OF THE CC GENE, A MEMBER OF THE DOPA DECARBOXYLASE GENE-CLUSTER OF DROSOPHILA - POSSIBLE TRANSLATIONAL REGULATION
SEQUENCE AND EXPRESSION OF THE CC GENE, A MEMBER OF THE DOPA DECARBOXYLASE GENE-CLUSTER OF DROSOPHILA - POSSIBLE TRANSLATIONAL REGULATION
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DOI：
10.1093/nar/14.15.6169
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发表时间：
1986-08-11
影响因子：
14.9
通讯作者：
MARSH, JL
中科院分区：
文献类型：
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作者：
EVELETH, DD;MARSH, JL
一个转录本已被定位在近端的多巴脱羧酶（Ddc）基因内的一组基因参与角质层的形成和儿茶酚胺代谢的果蝇。该基因位于Ddc基因5′端2.0kb处，转录方向与Ddc相同，被鉴定为l（2）37 Cc。我们描述了一种新的缺陷，它与以前的缺陷一起将thel（2）37 C和l（2）37 C定位于细胞遗传学区间5′-Ddc。我们给出了Cc基因的序列和相应的cDNA。Cc信息在负责致死性互补基团的大开放阅读框的5′端含有几个开放阅读框，表明Cc功能的表达可能受到间接调控。Cc基因在早期胚胎、晚期胚胎、三龄晚期幼虫和成虫中均有表达。我们讨论了这些研究结果的影响，在该地区的基因组织。
A transcript has been localized proximal to the dopa decarboxylase (Ddc) gene within a cluster of genes involved in cuticle formation and catecholamine metabolism in Drosophila. This gene, which has been identified asl(2)37Ccmaps 2.0kb from the 5′ end of theDdcgene and is transcribed in the same direction asDdc. We describe a new deficiency which in conjunction with previous deficiencies localizes thel(2)37Cbandl(2)37Ccloci to the cytogenetic interval 5′ toDdc. We present the sequence of theCcgene and corresponding cDNA. TheCcmessage contains several open reading frames 5′ to the large open reading frame responsible for the lethal complementation group, suggesting that expression ofCcfunction may be regulated translationally. TheCctranscript is expressed in early embryos, late embryos, late third instar larvae and adults. We discuss the implications of these findings with respect to the gene organization in the region.