Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity
Cisplatin carbonato complexes. Implications for uptake, antitumor properties, and toxicity
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DOI：
10.1021/ja053353c
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发表时间：
2005-09-21
影响因子：
15
通讯作者：
Dabrowiak, JC
中科院分区：
文献类型：
--
作者：
Centerwall, CR;Goodisman, J;Dabrowiak, JC
描述了水合顺铂与存在于培养基和血液中的碳酸盐的反应。首先形成的络合物是一氯一碳酸根合物，其在持续暴露于碳酸根时缓慢形成二碳酸根合络合物。在模拟治疗的条件下形成碳酸盐物质可能对顺铂的摄取、抗肿瘤特性和毒性具有重要意义。
The reaction of aquated cisplatin with carbonate which is present in culture media and blood is described. The first formed complex is a monochloro monocarbonato species, which upon continued exposure to carbonate slowly forms a biscarbonato complex. The formation of carbonato species under conditions that simulate therapy may have important implications for uptake, antitumor properties, and toxicity of cisplatin.