High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification
High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification
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DOI：
10.1016/j.biochi.2020.07.001
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发表时间：
2020-12-01
期刊：
影响因子：
3.9
通讯作者：
Vitale, Nicolas
中科院分区：
文献类型：
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作者：
Dugail, Isabelle;Amri, Ez-Zoubir;Vitale, Nicolas
越来越明显的是，除了衰老和各种心脏病，体重过重，特别是肥胖是COVID-19感染严重程度的主要风险因素。有趣的是，SARS-CoV-2的受体是ACE 2，它是血管紧张素受体家族的一员，具有相对较大的组织分布。这一观察结果可能解释了人类患者所描述的多种症状。脂肪组织也表达ACE 2，表明脂肪细胞可能被SARS-CoV-2感染。在这里，我们讨论了脂肪组织对感染严重程度的一些潜在贡献，并提出了肥胖患者代谢表型的一些方面，以帮助对严重疾病高风险个体进行分层。(C)2020 Elsevier B. V.和法国生物化学与生物分子学会（SFBBM）。All rights reserved.
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease. (C) 2020 Elsevier B.V. and Societe Francaise de Biochimie et Biologie Moleculaire (SFBBM). All rights reserved.