Neurologic Presentation of Probable Seronegative Paraneoplastic Encephalitis in a Woman With an Ovarian Teratoma
Neurologic Presentation of Probable Seronegative Paraneoplastic Encephalitis in a Woman With an Ovarian Teratoma
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DOI：
10.7759/cureus.8485
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发表时间：
2020-06-07
影响因子：
1.2
通讯作者：
Lee, Alice
中科院分区：
文献类型：
--
作者：
Chernyshkova, Irina;Estefan, Bebsy;Lee, Alice
我们描述了一个可能的自身免疫性脑炎的情况下，由于副肿瘤综合征的妇女卵巢畸胎瘤。患者可能会出现精神和神经症状，这是由抗N-甲基-D-天冬氨酸（抗NMDA）受体抗体引起的，该抗体是对穿过血脑屏障并损害边缘区脑组织的畸胎瘤的反应，从而引起脑炎。我们的病人表现为癫痫、肌阵挛和记忆问题，这是一个相对较新发现的罕见问题，但是如果不及时治疗，会使人非常虚弱。由于缺乏高度敏感的测试，这种诊断可能经常被错过。对于新发精神或神经症状的患者，自身免疫性脑炎必须列入鉴别诊断名单。
We describe a case of probable autoimmune encephalitis developed as a result of paraneoplastic syndrome in a woman with an ovarian teratoma. Patients may present with psychiatric and neurological symptoms, which are caused by anti-N-methyl-D-aspartate (anti-NMDA) receptor antibodies produced in response to a teratoma that crosses the blood-brain barrier and damages brain tissue in the limbic area, causing encephalitis. Our patient presented with seizures, myoclonus, and memory problems.This is a relatively newly discovered and rare problem; however, it can be quite debilitating if left untreated. This diagnosis may be often missed due to the absence of highly sensitive tests. Autoimmune encephalitis has to be on the list of differential diagnoses for patients with new-onset psychiatric or neurological symptoms.