A Role for the Superior Colliculus in Decision Criteria.

A Role for the Superior Colliculus in Decision Criteria.
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DOI:
10.1016/j.neuron.2017.12.006
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发表时间:
2018-01-03
期刊:
影响因子:
16.2
通讯作者:
Basso MA
Basso MA
中科院分区:
医学1区
文献类型:
--
作者:
Crapse TB;Lau H;Basso MA

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简单的决策源于对感官证据的评估。但决策不仅仅取决于证据。个人建立影响他们反应方式的内部决策标准。大脑中决策标准的建立位置和方式仍然知之甚少。在这里,我们表明上丘(SC)的神经元活动可以预测决策标准的变化。使用新颖的“是-否”任务将决策标准的变化与决策敏感性的变化分开,并计算敏感性和标准的神经元测量,我们发现无论选择报告的位置如何,SC 神经元活动都与决策标准相关。我们还表明,对 SC 内活动的电气操纵会产生与决策标准变化一致的决策变化,并且在很大程度上独立于选择报告位置。我们的相关性和因果性结果共同提供了强有力的证据,证明 SC 活动表明了决策标准的位置。 Crapse 等人描述了与决策标准而不是决策变量相关的上丘神经元活动。通过微刺激操纵 SC 神经元活动可预见地改变了标准,证明了 SC 在决策标准中的因果作用。
Simple decisions arise from the evaluation of sensory evidence. But decisions are determined by more than just evidence. Individuals establish internal, decision criteria that influence how they respond. Where or how decision criteria are established in the brain remains poorly understood. Here, we show that neuronal activity in the superior colliculus (SC) predicts changes in decision criteria. Using a novel ‘Yes-No’ task that isolates changes in decision criterion from changes in decision sensitivity, and computing neuronal measures of sensitivity and criterion, we find that SC neuronal activity correlates with the decision criterion regardless of the location of the choice report. We also show that electrical manipulation of activity within the SC produces changes in decisions consistent with changes in decision criteria and are largely independent of the choice report location. Our correlational and causal results together provide strong evidence that SC activity signals the position of a decision criterion. Crapse, et al., describe neuronal activity in the superior colliculus correlating with decision criteria, rather than a decision variable. Manipulation of SC neuronal activity with microstimulation changed the criterion predictably, demonstrating a causal role for the SC in decision criteria.
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