The Gene Sr33, an Ortholog of Barley Mla Genes, Encodes Resistance to Wheat Stem Rust Race Ug99
The Gene Sr33, an Ortholog of Barley Mla Genes, Encodes Resistance to Wheat Stem Rust Race Ug99
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DOI：
10.1126/science.1239028
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发表时间：
2013-08-16
期刊：
影响因子：
56.9
通讯作者：
Lagudah, Evans
中科院分区：
文献类型：
--
作者：
Periyannan, Sambasivam;Moore, John;Lagudah, Evans
小麦秆锈病是由禾柄锈菌（Puccinia graminis f.）小麦（Triticum aestivum）是一种危害面包小麦（Triticum aestivum）的病原菌。被统称为“Ug99”的新的毒性小种已经出现，它们威胁着全球小麦生产。从野生近缘节节麦（Aegilops tauschii）渗入面包小麦中的小麦基因Sr33赋予对包括Ug 99小种群在内的多种茎锈病小种的抗性。我们克隆了Sr33，它编码卷曲螺旋，核苷酸结合，富含亮氨酸的重复蛋白。Sr33与大麦（Hordeum vulgare）的抗白粉病基因Mla同源，该基因赋予对小麦白粉病的抗性。大麦锈病菌小麦Sr33基因的功能独立于RAR 1、SGT1和HSP 90分子伴侣。来自不同收集的Ae. tauschii将Sr33抗性的起源定位在里海南部海岸附近。
Wheat stem rust, caused by the fungus Puccinia graminis f. sp. tritici, afflicts bread wheat (Triticum aestivum). New virulent races collectively referred to as "Ug99" have emerged, which threaten global wheat production. The wheat gene Sr33, introgressed from the wild relative Aegilops tauschii into bread wheat, confers resistance to diverse stem rust races, including the Ug99 race group. We cloned Sr33, which encodes a coiled-coil, nucleotide-binding, leucine-rich repeat protein. Sr33 is orthologous to the barley (Hordeum vulgare) Mla mildew resistance genes that confer resistance to Blumeria graminis f. sp. hordei. The wheat Sr33 gene functions independently of RAR1, SGT1, and HSP90 chaperones. Haplotype analysis from diverse collections of Ae. tauschii placed the origin of Sr33 resistance near the southern coast of the Caspian Sea.