Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.
Intergenerational Transmission of Enhanced Seizure Susceptibility after Febrile Seizures.
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高热惊厥后癫痫易感性增强的代际传递
DOI：
10.1016/j.ebiom.2017.02.006
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发表时间：
2017-03
期刊：
影响因子：
11.1
通讯作者：
Chen Z
中科院分区：
文献类型：
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作者：
Wu D;Feng B;Dai Y;Wu X;Chen B;Xu C;Tang Y;Wang K;Zhang S;Wang S;Luo B;Chen Z
发育早期的环境暴露在以后的生活中对疾病的易感性中起作用。在这里，我们证明，暴露在高温环境中引起的长时间热性癫痫发作不仅在这些高温处理过的大鼠中，而且在它们未来的后代中，即使后代从未经历过热性癫痫发作，也会增加癫痫发作的易感性。这种跨代传播是强度依赖的，主要是由母亲传给后代。这种传播与DNA甲基化有关。因此，我们的研究支持“拉马克”式的发病机制和表观遗传因素在神经系统疾病中的关键作用。FS诱导的癫痫易感性增强是跨代遗传的。跨代传播依赖于fs强度。跨代传播主要是由母亲传给后代。这种传播与DNA甲基化有关。发育时期的环境经验起着至关重要的作用。早期FS诱导的癫痫易感性的增强是否会传递给未受影响的后代，以及这种跨代传递的潜在特征。在这里，我们使用了一个完善的FS模型，表明延长热性癫痫发作不仅会增加这些高温治疗大鼠的癫痫易感性，而且会增加它们未来非FS的后代的癫痫易感性。这种跨代传播是强度依赖的，主要从母亲传给后代，并与DNA甲基化有关。
Environmental exposure early in development plays a role in susceptibility to disease in later life. Here, we demonstrate that prolonged febrile seizures induced by exposure of rat pups to a hyperthermic environment enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future offspring, even if the offspring never experience febrile seizures. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring. The transmission was associated with DNA methylation. Thus, our study supports a “Lamarckian”-like mechanism of pathogenesis and the crucial role of epigenetic factors in neurological conditions. FS induced enhanced seizure susceptibility was transgenerational transmitted. The transgenerational transmission was FS-intensity dependent. The transgenerational transmission was mainly from mothers to their offspring. The transmission was associated with DNA methylation. Environmental experience during developmental period plays a critical role. Whether the enhanced seizure susceptibility induced by early life FS transmitted to their unaffected offspring and the underlie characteristic of this transgenerational transmission Here, we used a well-established FS models showed that prolonged febrile seizures enhance seizure susceptibility not only in these hyperthermia-treated rats but also in their future non-FS offspring. This transgenerational transmission was intensity-dependent and was mainly from mothers to their offspring, and was associated with DNA methylation.