CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B.
CD1 presents antigens from a gram-negative bacterium, Haemophilus influenzae type B.
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CD1 呈递来自革兰氏阴性细菌 B 型流感嗜血杆菌的抗原。
DOI：
10.1128/iai.66.8.3523-3526.1998
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发表时间：
1998
影响因子：
3.1
通讯作者：
Braun,J
中科院分区：
文献类型：
--
作者：
Fairhurst,RM;Wang,CX;Sieling,PA;Modlin,RL;Braun,J
Human CD1 is a family of nonpolymorphic major histocompatibility complex class I-like molecules capable of presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4−CD8−) as well as CD8+T cells. Structural similarities between LAM and the capsular polysaccharides of gram-negative bacteria led us to consider the latter as candidate CD1 ligands. We derived two CD1-restricted DN T-cell populations which proliferated toHaemophilus influenzaetype b (Hib) antigen. One T-cell population also proliferated to proteinase K-treated Hib antigen, suggesting that it recognized a nonpeptide. Our work thus expands the universe of T cell antigens to include nonpeptides distinct from mycobacterial lipids and suggests a potential role for CD1-restricted T cells in immunity to Hib.
