Models of axon guidance and bundling during development
Models of axon guidance and bundling during development
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DOI：
10.1098/rspb.1999.0913
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发表时间：
1999-11-07
影响因子：
4.7
通讯作者：
van Ooyen, A
中科院分区：
文献类型：
--
作者：
Hentschel, HGE;van Ooyen, A
扩散性化学吸引剂和化学排斥剂，连同接触吸引和排斥，在神经元和它们的目标之间建立联系中有牵连。在这里，我们研究了这些扩散信号和接触信号如何参与从轴突的捆绑，轴突束向其目标的引导，到单个目标的解绑和最终的神经支配的整个事件序列。通过计算机模拟，我们研究了为这些过程提出的一些特定机制的优点和缺点。
Diffusible chemoattractants and chemorepellants, together with contact attraction and repulsion, have been implicated in the establishment of connections between neurons and their targets. Here we study how such diffusible and contact signals can be involved in the whole sequence of events from bundling of axons, guidance of axon bundles towards their targets, to debundling and the final innervation of individual targets. By means of computer simulations, we investigate the strengths and weaknesses of a number of particular mechanisms that have been proposed for these processes.