hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
hOGG1 Ser326Cys polymorphism and risk of childhood acute lymphoblastic leukemia in a Chinese population
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hOGG1 Ser326Cys 多态性与中国人群儿童急性淋巴细胞白血病的风险
DOI：
10.1111/j.1349-7006.2011.01928.x
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Fang, Yongjun
中科院分区：
文献类型：
--
作者：
Li, Qian;Huang, Lizhen;Fang, Yongjun
由活性氧引起的氧化性DNA损伤可在DNA中产生8-氧代鸟嘌呤（8-oxoG），其被误读并导致G：C -> T：A颠换。这可能是致癌的。通过碱基切除修复途径修复8-oxoG涉及人8-oxoG DNA糖基化酶1（hOGG 1）的活性。越来越多的证据表明，hOGG 1的Ser 326 Cys多态性影响hOGG 1的活性，并可能作为一个遗传标记，对几种癌症的易感性。为了确定该多态性是否与中国儿童急性淋巴细胞白血病（ALL）的风险有关，我们在一项病例对照研究中对415例病例和511例对照进行了hOGG 1 Ser 326 Cys多态性（rs 1052133）基因分型。我们发现，hOGG 1 Ser 326 Cys多态性在病例组和对照组中的基因型分布存在显著差异（P = 0.046），联合基因型Ser/Ser和Ser/Cys与ALL风险显著降低相关（调整后的比值比[OR] = 0.66，95%置信区间[CI] = 0.49-0.88，P = 0.005）。此外，我们发现，高风险ALL的风险降低（校正OR = 0.60，95% CI = 0.40-0.88，P = 0.005），低风险ALL（校正OR = 0.68，95%CI = 0.47-0.99，P = 0.042），B表型ALL（校正OR = 0.63，95%CI = 0.46-0.86，P = 0.003）。我们的研究结果表明，hOGG 1 Ser 326 Cys多态性与儿童ALL的易感性在中国的人口。（Cancer Sci 2011; 102：1123-1127）。
Oxidative DNA damage caused by reactive oxygen species can produce 8-oxoguanine (8-oxoG) in DNA, which is misread and leads to G:C -> T:A transversions. This can be carcinogenic. Repair of 8-oxoG by the base excision repair pathway involves the activity of human 8-oxoG DNA glycosylase 1 (hOGG1). Accumulating evidence suggests that the hOGG1 Ser326Cys polymorphism affects the activity of hOGG1 and might serve as a genetic marker for susceptibility to several cancers. To determine whether this polymorphism is associated with risk of childhood acute lymphoblastic leukemia (ALL) in Chinese children, we genotyped the hOGG1 Ser326Cys polymorphism (rs1052133) in a case-control study including 415 cases and 511 controls. We found that there was a significant difference in the genotype distributions of the hOGG1 Ser326Cys polymorphism between cases and controls (P = 0.046), and the combined genotypes Ser/Ser and Ser/Cys were associated with a statistically significantly decreased risk of ALL (adjusted odds ratio [OR] = 0.66, 95% confidence interval [CI] = 0.49-0.88, P = 0.005). Furthermore, we found a decreased risk for high risk ALL (adjusted OR = 0.60, 95% CI = 0.40-0.88, P = 0.005), low risk ALL (adjusted OR = 0.68, 95% CI = 0.47-0.99, P = 0.042), and B-phenotype ALL (adjusted OR = 0.63, 95% CI = 0.46-0.86, P = 0.003) among children with the Ser/Ser and Ser/Cys genotypes. Our results suggest that the hOGG1 Ser326Cys polymorphism is associated with susceptibility to childhood ALL in a Chinese population. (Cancer Sci 2011; 102: 1123-1127).