Graves' disease associated with spasmodic truncal flexion
Graves' disease associated with spasmodic truncal flexion
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DOI：
10.1016/j.parkreldis.2004.08.004
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发表时间：
2005-03-01
影响因子：
4.1
通讯作者：
Lim, ECH
中科院分区：
文献类型：
--
作者：
Loh, LM;Hum, AYM;Lim, ECH
一位40岁的中国男性因类似肌阵挛的1-2 Hz痉挛性躯干屈曲而入院。他被认为是甲状腺毒性，并已默认抗甲状腺治疗。临床检查显示躯干屈曲来自腹直肌的收缩，不涉及四肢或面部，也没有在睡眠中抽搐。他在生化方面有甲状腺毒性。用氯硝西泮和丙基硫氧嘧啶治疗导致在接下来的3周内肌阵挛痉挛消退。他在接下来的3个月内停止服用氯硝西泮，肌阵挛没有复发。他一直很好，直到他停止服用抗甲状腺药物9个月后，当他再次出现痉挛性躯干抽搐。生化检查证实他当时甲状腺功能亢进。在接受抗甲状腺药物治疗的一个月内，这些运动停止了，此后他一直很好。脑部和胸椎MRI无异常。已知甲状腺毒症会引起舞蹈病和震颤，但很少与肌阵挛相关。(c)2004爱思唯尔有限公司保留所有权利。
A 40-year-old Chinese man was admitted with 1-2 Hz spasmodic truncal flexion resembling myoclonus. He was known to be thyrotoxic, and had defaulted antithyroid therapy. Clinical examination revealed truncal flexion from contraction of the rectus abdominis, with no involvement of limbs or face and no jerking in sleep. He was biochemically thyrotoxic. Treatment with clonazepam and propylthiouracil resulted in resolution of the myoclonic jerks within the next 3 weeks. He stopped taking clonazepam within the next 3 months with no recurrence of myoclonus. He remained well until he stopped taking his antithyroid medications 9 months later, when he developed spasmodic truncal jerking again. Biochemical tests confirmed that he was hyperthyroid at this time. These movements ceased within a month of compliance with antithyroid therapy, and he has been well since. MRI of the brain and thoracic spine were unremarkable. Thyrotoxicosis is known to cause chorea and tremors, and has rarely been described in association with myoclonus. (c) 2004 Elsevier Ltd. All rights reserved.