Lymphoid tissue homing chemokines are expressed in chronic inflammation
Lymphoid tissue homing chemokines are expressed in chronic inflammation
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DOI：
10.1016/s0002-9440(10)64981-4
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发表时间：
2000-04-01
影响因子：
6
通讯作者：
Ruddle, NH
中科院分区：
文献类型：
--
作者：
Hjelmström, P;Fjell, J;Ruddle, NH
次级淋巴组织趋化因子(SLC)和B淋巴细胞趋化因子(BLC)是与淋巴细胞和树突状细胞在淋巴器官的运输有关的归巢趋化因子，淋巴毒素-α(LT-α)是淋巴器官发育的关键细胞因子，在次级淋巴器官发育过程中对SLC和BLC的表达起重要作用。在此，我们报道了转基因LTα的表达在成年动物中诱导炎症和SLC和BLC的异位表达。在炎症组织中，LTβ不是诱导BLC和SLC所必需的，相反，肿瘤坏死因子受体-1被发现在LTα介导的这些趋化因子的诱导中起重要作用。LTα的异位表达与类似于有组织的淋巴组织的慢性炎症有关，这种淋巴新生也可以在几种慢性炎症性疾病中看到，包括在糖尿病前期非肥胖糖尿病(NOD)小鼠的胰腺中。糖尿病前期NOD小鼠胰腺中也可见SLC的表达。这项研究表明BLC和SLC与慢性炎症有关，并提供了进一步的证据，证明LTα在发育过程和炎症过程中都协调淋巴器官的生成。
Secondary lymphoid tissue chemokine (SLC) and B lymphocyte chemoattractant (BLC) are homing chemokines that have been implicated in the trafficking of lymphocytes and dendritic cells in lymphoid organs, Lymphotoxin-alpha (LT alpha), a cytokine crucial for development of lymphoid organs, is important for expression of SLC and BLC in secondary lymphoid organs during development. Here we report that transgenic expression of LT alpha induces inflammation and ectopic expression of SLC and BLC in the adult animal. LT beta was not necessary for induction of BLC and SLC in inflamed tissues, whereas, in contrast, tumor necrosis factor receptor-1 was found to be important for the LT alpha-mediated induction of these chemokines. The ectopic expression of LT alpha is associated with a chronic inflammation that closely resembles organized lymphoid tissue and this lymphoid neogenesis can also be seen in several chronic inflammatory diseases, including in the pancreas of the prediabetic nonobese diabetic (NOD) mouse. Expression of SLC was also observed in the pancreas of prediabetic NOD mice. This study implicates BLC and SLC in chronic inflammation and presents further evidence that LT alpha orchestrates lymphoid organogenesis both during development and in inflammatory processes.